The Herbert H & Grace A. Dow College of Health Professions, Nutrition, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Nutrasource/GRAS Associates, Scientific Affairs, Guelph, ON N1G0B4, Canada.
Nutrients. 2021 Mar 30;13(4):1127. doi: 10.3390/nu13041127.
Cognitive function is a key aspect of healthy aging. Inflammation associated with normal aging, also called inflammaging is a primary risk factor for cognitive decline. A diet high in fruits and vegetable and lower in calories, particularly a Mediterranean Diet, may lower the risk of age-related cognitive decline due in part to the associated high intake of antioxidants and polyphenols. A phenolic, Palm Fruit Bioactive complex (PFBc) derived from the extraction process of palm oil from oil palm fruit (), is reported to offset inflammation due to its high antioxidant, especially vitamin E, and polyphenol content. The benefit is thought to be achieved via the influence of antioxidants on gene expression. It is the purpose of this comprehensive review to discuss the etiology, including gene expression, of mild cognitive impairment (MCI) specific to dietary intake of antioxidants and polyphenols and to focus on the potential impact of nutritional interventions specifically PFBc has on MCI. Several in vitro, in vivo and animal studies support multiple benefits of PFBc especially for improving cognitive function via anti-inflammatory and antioxidant mechanisms. While more human studies are needed, those completed thus far support the benefit of consuming PFBc to enhance cognitive function via its anti-inflammatory antioxidant functions.
认知功能是健康老龄化的关键方面。与正常衰老相关的炎症，也称为炎症衰老，是认知能力下降的主要风险因素。高水果和蔬菜、低卡路里的饮食，特别是地中海饮食，可能会降低与年龄相关的认知能力下降的风险，部分原因是与高抗氧化剂和多酚的摄入量有关。一种来源于油棕果实提取棕榈油过程中的酚类 Palm Fruit Bioactive complex（PFBc），由于其高抗氧化剂，特别是维生素 E 和多酚含量，据称可以抵消炎症。这种益处被认为是通过抗氧化剂对基因表达的影响来实现的。本综述的目的是讨论轻度认知障碍（MCI）的病因，包括抗氧化剂和多酚的饮食摄入的基因表达，并重点讨论营养干预措施，特别是 PFBc 对 MCI 的潜在影响。几项体外、体内和动物研究支持 PFBc 的多种益处，特别是通过抗炎和抗氧化机制改善认知功能。虽然还需要更多的人体研究，但迄今为止完成的研究支持通过其抗炎抗氧化功能消耗 PFBc 来增强认知功能的益处。
