Pharmacoepidemiology and Drug Safety Unit, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka 1205, Bangladesh.
Molecules. 2020 Nov 5;25(21):5159. doi: 10.3390/molecules25215159.
Neurodegenerative diseases (ND) can be characterized by degradation and subsequent loss of neurons. ND has been identified as the leading cause of disability-adjusted life years (DALYs) worldwide and is associated with various risk factors such as ageing, certain genetic polymorphisms, inflammation, immune and metabolic conditions that may induce elevated reactive oxygen species (ROS) release and subsequent oxidative stress. Presently, no specific cure or prevention is available for ND patients; the symptoms can be only alleviated via drug treatment or surgery. The existing pharmacological treatments are only available for partial treatment of the symptoms. A natural product known as oil palm phenolics (OPP), which is high in antioxidant, could become a potential supplementary antioxidant for neurodegenerative health. OPP is a water-soluble extract from palm fruit that demonstrated medicinal properties including anti-tumor, anti-diabetic and neuroprotective effects. In this review, OPP was proposed for its neuroprotective effects via several mechanisms including antioxidant and anti-inflammatory properties. Besides, OPP has been found to modulate the genes involved in neurotrophic activity. The evidence and proposed mechanism of OPP on the neuroprotective health may provide a comprehensive natural medicine approach to alleviate the symptoms of neurodegenerative diseases.
神经退行性疾病（ND）的特征是神经元的退化和随后的丧失。ND 已被确定为全球导致残疾调整生命年（DALYs）的主要原因，与各种风险因素有关，如衰老、某些遗传多态性、炎症、免疫和代谢状况，这些因素可能导致活性氧（ROS）释放增加和随后的氧化应激。目前，ND 患者没有特定的治疗方法或预防措施；只能通过药物治疗或手术来缓解症状。现有的药物治疗方法仅适用于部分症状的治疗。一种被称为油棕酚（OPP）的天然产物，具有很高的抗氧化能力，可能成为神经退行性健康的潜在补充抗氧化剂。OPP 是一种从棕榈果实中提取的水溶性提取物，具有抗肿瘤、抗糖尿病和神经保护作用。在这篇综述中，OPP 被提出通过几种机制具有神经保护作用，包括抗氧化和抗炎特性。此外，OPP 已被发现可调节参与神经营养活性的基因。OPP 对神经保护健康的证据和提出的机制可能为缓解神经退行性疾病的症状提供一种全面的天然药物方法。
