大鼠肝脏中磷脂酰胆碱合成的调控及胆碱激酶的调节作用。来自必需脂肪酸缺乏大鼠的证据。
Control of phosphatidylcholine synthesis and the regulatory role of choline kinase in rat liver. Evidence from essential-fatty acid-deficient rats.
作者信息
Infante J P, Kinsella J E
出版信息
Biochem J. 1978 Nov 15;176(2):631-3. doi: 10.1042/bj1760631.
Abstract
Choline kinase and phosphocholine cytidylytransferase catalyse the rate-limiting steps of the cytidine pathway for the synthesis of phosphatidylcholine [Infante (1977) Biochem. J. 167, 847--849]. Essential-fatty acid deficiency induces a 3.5-fold increase in the specific activity of choline kinase, whereas the specific activity of the cytidylytransferase remains unchanged in rat liver. This change in specific activity accounts for the calculated increase in flux through the cytidine pathway produced in vivo by the same dietary state [Trewhella & Collins (1973 Biochim. Biophys. Acta 296, 34--50], thus confirming the fact that choline kinase has a regulatory role in the cytidine pathway for the synthesis of phosphatidylcholine.
摘要
胆碱激酶和磷酸胆碱胞苷转移酶催化合成磷脂酰胆碱的胞苷途径的限速步骤[英方特（1977年），《生物化学杂志》167卷，847 - 849页]。必需脂肪酸缺乏会使大鼠肝脏中胆碱激酶的比活性增加3.5倍，而胞苷转移酶的比活性保持不变。比活性的这种变化解释了在相同饮食状态下体内通过胞苷途径产生的通量计算得出的增加[特里韦拉和柯林斯（1973年），《生物化学与生物物理学报》296卷，34 - 50页]，从而证实了胆碱激酶在磷脂酰胆碱合成的胞苷途径中具有调节作用这一事实。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement.组织脂质中三烯酸与四烯酸的比例作为衡量必需脂肪酸需求量的指标。
J Nutr. 1960 Mar;70(3):405-10. doi: 10.1093/jn/70.3.405.
3
Biosynthetic pathways in the formation of individual molecular species of rat liver phospholipids.
Biochim Biophys Acta. 1969 Apr 29;176(3):635-7. doi: 10.1016/0005-2760(69)90231-8.
4
Specificity for incorporation of choline and ethanolamine into rat-liver microsomal lecithins.胆碱和乙醇胺掺入大鼠肝脏微粒体卵磷脂的特异性。
Biochim Biophys Acta. 1968 Mar 4;152(2):418-21. doi: 10.1016/0005-2760(68)90054-4.
5
Initial esterification and conversion of intraportally injected (I-14C)linoleic acid in rat liver.大鼠肝脏中门静脉注射的（I-14C）亚油酸的初始酯化和转化
Biochim Biophys Acta. 1970 Oct 6;218(1):57-70.
6
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Vitam Horm. 1967;25:1-87. doi: 10.1016/s0083-6729(08)60033-3.
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