Infante J P, Kinsella J E
Biochem J. 1978 Nov 15;176(2):631-3. doi: 10.1042/bj1760631.
Choline kinase and phosphocholine cytidylytransferase catalyse the rate-limiting steps of the cytidine pathway for the synthesis of phosphatidylcholine [Infante (1977) Biochem. J. 167, 847--849]. Essential-fatty acid deficiency induces a 3.5-fold increase in the specific activity of choline kinase, whereas the specific activity of the cytidylytransferase remains unchanged in rat liver. This change in specific activity accounts for the calculated increase in flux through the cytidine pathway produced in vivo by the same dietary state [Trewhella & Collins (1973 Biochim. Biophys. Acta 296, 34--50], thus confirming the fact that choline kinase has a regulatory role in the cytidine pathway for the synthesis of phosphatidylcholine.
胆碱激酶和磷酸胆碱胞苷转移酶催化合成磷脂酰胆碱的胞苷途径的限速步骤[英方特（1977年），《生物化学杂志》167卷，847 - 849页]。必需脂肪酸缺乏会使大鼠肝脏中胆碱激酶的比活性增加3.5倍，而胞苷转移酶的比活性保持不变。比活性的这种变化解释了在相同饮食状态下体内通过胞苷途径产生的通量计算得出的增加[特里韦拉和柯林斯（1973年），《生物化学与生物物理学报》296卷，34 - 50页]，从而证实了胆碱激酶在磷脂酰胆碱合成的胞苷途径中具有调节作用这一事实。
