用于合成磷脂酰胆碱和磷脂酰乙醇胺的胞苷途径中的限速步骤。
Rate-limiting steps in the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine.
作者信息
Infante J P
出版信息
Biochem J. 1977 Dec 1;167(3):847-9. doi: 10.1042/bj1670847.
Abstract
An analysis of the available data on the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine, by the logic derived from the theoretical principles of metabolic regulation, shows that the first two reactions catalysed by choline (ethanolamine) kinase and phosphocholine (phosphoethanolamine) cytidylyltransferase are rate-limiting, whereas the phosphocholine (phosphoethanolamine) transferase step is near equilibrium in rat liver.
摘要
根据代谢调节理论原则推导的逻辑，对合成磷脂酰胆碱和磷脂酰乙醇胺的胞苷途径现有数据进行分析表明，由胆碱（乙醇胺）激酶和磷酸胆碱（磷酸乙醇胺）胞苷酰转移酶催化的前两个反应是限速反应，而磷酸胆碱（磷酸乙醇胺）转移酶步骤在大鼠肝脏中接近平衡。
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