2-氯乙基三甲基氯化铵对乳腺组织中磷脂酰胆碱合成的抑制作用。
Inhibition of phosphatidylcholine synthesis in mammary tissue by 2-chloroethyltrimethylammonium chloride.
作者信息
Infante J P, Kinsella J E
出版信息
Biochem J. 1973 Jul;134(3):825-7. doi: 10.1042/bj1340825.
Abstract
The incorporation of choline into phosphatidylcholine in mammary tissue from lactating cows is impeded by 2-chloroethyltrimethylammonium chloride at concentrations ranging from 0.3 to 9mm. This compound is a non-competitive inhibitor of choline kinase (K(m) 0.25mm), having K(i) 17mm. It is suggested that 2-chloroethyltrimethylammonium chloride may inhibit choline entry into the tissue.
摘要
在浓度为0.3至9毫摩尔的范围内，2-氯乙基三甲基氯化铵会阻碍泌乳奶牛乳腺组织中胆碱掺入磷脂酰胆碱。该化合物是胆碱激酶的非竞争性抑制剂（米氏常数为0.25毫摩尔），抑制常数为17毫摩尔。有人提出，2-氯乙基三甲基氯化铵可能会抑制胆碱进入该组织。
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