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1
Inhibition of phosphatidylcholine synthesis in mammary tissue by 2-chloroethyltrimethylammonium chloride.2-氯乙基三甲基氯化铵对乳腺组织中磷脂酰胆碱合成的抑制作用。
Biochem J. 1973 Jul;134(3):825-7. doi: 10.1042/bj1340825.
2
Rat and human mammary tissue can synthesize choline moiety via the methylation of phosphatidylethanolamine.大鼠和人类乳腺组织可通过磷脂酰乙醇胺的甲基化作用合成胆碱部分。
Biochem J. 1988 Dec 15;256(3):821-8. doi: 10.1042/bj2560821.
3
Effects of bovine somatotropin on beta-casein mRNA levels in mammary tissue of lactating cows.牛生长激素对泌乳奶牛乳腺组织中β-酪蛋白mRNA水平的影响。
J Dairy Sci. 2005 Aug;88(8):2806-12. doi: 10.3168/jds.S0022-0302(05)72960-X.
4
Effect of alkyl-lysophospholipids on phosphatidylcholine biosynthesis in leukemic cell lines.
Exp Hematol. 1985 Aug;13(7):629-33.
5
Glucocorticoid binding in mammary tissue slices of cattle in various reproductive states.处于不同生殖状态的奶牛乳腺组织切片中的糖皮质激素结合情况。
J Dairy Sci. 1976 Nov;59(11):1890-6. doi: 10.3168/jds.S0022-0302(76)84458-X.
6
Staphylococcus aureus intramammary challenge in non-lactating mammary glands stimulated to rapidly grow and develop with estradiol and progesterone.用雌二醇和孕酮刺激快速生长和发育的非泌乳乳腺中的金黄色葡萄球菌乳腺内挑战。
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7
Membrane proliferation and phosphatidylcholine synthesis in normal, preneoplastic, and neoplastic mammary gland tissues in C3H mice.C3H小鼠正常、癌前和肿瘤性乳腺组织中的膜增殖与磷脂酰胆碱合成
Cancer Res. 1972 Dec;32(12):2834-41.
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Duodenal infusion of α-linolenic acid affects fatty acid metabolism in the mammary gland of lactating dairy cows.十二指肠内输注α-亚麻酸影响泌乳奶牛乳腺的脂肪酸代谢。
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9
Thymidine incorporation by lactating mammary epithelium during compensatory mammary growth in beef cattle.肉牛代偿性乳腺生长期间泌乳乳腺上皮细胞的胸苷掺入情况。
J Dairy Sci. 1990 Nov;73(11):3094-103. doi: 10.3168/jds.S0022-0302(90)78997-7.
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Effect of exogenous bovine somatotropin on mammary lipid metabolism and milk yield in lactating dairy cows.
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引用本文的文献

1
Effects of analogles of ethanolamine and choline on phospholipid metabolism in rat hepatocytes.乙醇胺和胆碱类似物对大鼠肝细胞磷脂代谢的影响。
Biochem J. 1977 Dec 15;168(3):401-8. doi: 10.1042/bj1680401.
2
Rate-limiting steps in the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine.用于合成磷脂酰胆碱和磷脂酰乙醇胺的胞苷途径中的限速步骤。
Biochem J. 1977 Dec 1;167(3):847-9. doi: 10.1042/bj1670847.
3
Control of phosphatidylcholine synthesis and the regulatory role of choline kinase in rat liver. Evidence from essential-fatty acid-deficient rats.大鼠肝脏中磷脂酰胆碱合成的调控及胆碱激酶的调节作用。来自必需脂肪酸缺乏大鼠的证据。
Biochem J. 1978 Nov 15;176(2):631-3. doi: 10.1042/bj1760631.
4
Phospholipid synthesis in mammary tissue. Choline and ethanolamine kinases: kinetic evidence for two discrete active sites.乳腺组织中的磷脂合成。胆碱激酶和乙醇胺激酶：两个离散活性位点的动力学证据。
Lipids. 1976 Oct;11(10):727-35. doi: 10.1007/BF02533046.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Cultivation and properties of bovine mammary cell cultures.牛乳腺细胞培养物的培养与特性
Exp Cell Res. 1961 Mar;23:373-85. doi: 10.1016/0014-4827(61)90046-5.
3
Effect of Cycocel derivatives and gibberellin on choline kinase and choline metabolism.矮壮素衍生物和赤霉素对胆碱激酶及胆碱代谢的影响
Plant Physiol. 1966 Feb;41(2):313-8. doi: 10.1104/pp.41.2.313.
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Choline kinase and phosphorylcholine phosphatase in plants.植物中的胆碱激酶和磷酸胆碱磷酸酶。
Plant Physiol. 1966 Feb;41(2):307-12. doi: 10.1104/pp.41.2.307.
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Carrier-mediated transport of choline into synaptic nerve endings.载体介导的胆碱向突触神经末梢的转运。
J Biol Chem. 1969 Jun 25;244(12):3258-63.
6
Choline kinase; assay and partial purification.胆碱激酶；测定与部分纯化。
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7
A novel stimulatory action of phosphorylcholine plus cytidine 5'-triphosphate on protein synthesis in a cell-free system.
J Biol Chem. 1971 May 10;246(9):3008-17.
8
Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. 3. Choline transport and uptake by simple diffusion and lack of direct exchange with phosphatidylcholine.悬浮培养的大鼠肝癌细胞中的胆碱代谢与膜形成。3. 胆碱通过简单扩散的转运与摄取以及与磷脂酰胆碱缺乏直接交换
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Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.渗透作为诺维科夫肝癌细胞中尿苷和胆碱磷酸化及其掺入大分子过程中的限速步骤。苯乙醇、潘生丁和腺苷的竞争性抑制作用。
Biochemistry. 1969 Dec;8(12):4782-9. doi: 10.1021/bi00840a020.
10
Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. II. Phosphatidylcholine synthesis during growth cycle and fluctuation of mitochondrial density.悬浮培养的大鼠肝癌细胞中的胆碱代谢与膜形成。II. 生长周期中的磷脂酰胆碱合成及线粒体密度的波动
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2-氯乙基三甲基氯化铵对乳腺组织中磷脂酰胆碱合成的抑制作用。

Inhibition of phosphatidylcholine synthesis in mammary tissue by 2-chloroethyltrimethylammonium chloride.

作者信息

Infante J P, Kinsella J E

出版信息

Biochem J. 1973 Jul;134(3):825-7. doi: 10.1042/bj1340825.

DOI:10.1042/bj1340825
PMID:4749281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1177882/
Abstract

The incorporation of choline into phosphatidylcholine in mammary tissue from lactating cows is impeded by 2-chloroethyltrimethylammonium chloride at concentrations ranging from 0.3 to 9mm. This compound is a non-competitive inhibitor of choline kinase (K(m) 0.25mm), having K(i) 17mm. It is suggested that 2-chloroethyltrimethylammonium chloride may inhibit choline entry into the tissue.

摘要

在浓度为0.3至9毫摩尔的范围内，2-氯乙基三甲基氯化铵会阻碍泌乳奶牛乳腺组织中胆碱掺入磷脂酰胆碱。该化合物是胆碱激酶的非竞争性抑制剂（米氏常数为0.25毫摩尔），抑制常数为17毫摩尔。有人提出，2-氯乙基三甲基氯化铵可能会抑制胆碱进入该组织。