Heinrich-Heine-University, Duesseldorf, Germany.
Stroke. 2011 Aug;42(8):2342-50. doi: 10.1161/STROKEAHA.111.613422. Epub 2011 Jul 7.
A major challenge to effective treatment after stroke is the restoration of neuronal function. In recent years, cell-based therapies for stroke have been explored in experimental animal models, and the results have suggested behavioral improvements. However, the anatomic targets of a cell-based stroke therapy and the relationship of cell grafts to post stroke reorganization are poorly understood, which results in difficulties defining strategies for neuronal substitution. Given that stroke causes a variety of secondary changes at locations beyond the infarct lesion, overcoming these difficulties is even more important.
We describe which brain structures and cell types are candidates for substitution and how new neuronal functionality could be implemented in a damaged brain by capitalizing on current concepts of post stroke plasticity.
脑卒中后有效治疗的一个主要挑战是神经元功能的恢复。近年来，针对脑卒中的细胞疗法已在实验动物模型中进行了探索，结果表明其具有改善行为的作用。然而，细胞脑卒中疗法的解剖学靶点以及细胞移植与脑卒中后重组的关系尚不清楚，这导致确定神经元替代策略存在困难。鉴于脑卒中会导致梗死病灶以外的部位发生多种继发性变化，克服这些困难就显得尤为重要。
我们描述了哪些脑结构和细胞类型适合替代，以及如何通过利用脑卒中后可塑性的现有概念，在受损的大脑中实现新的神经元功能。
