Eleftherianos Ioannis, Schneider David
Department of Biological Sciences, George Washington University, Washington, DC, USA.
Fly (Austin). 2011 Jul-Sep;5(3):247-54. doi: 10.4161/fly.5.3.17028. Epub 2011 Jul 1.
Drosophila has been established as useful model for infectious diseases because it allows large numbers of whole animals to be studied and provides powerful genetic tools and conservation with signaling and pathogenesis mechanisms in vertebrates. During the past twenty years, significant progress has been made on the characterization of innate immune responses against various pathogenic organisms in flies (Fig. 1). In this year's Drosophila Research Conference, which was held in San Diego (March 30-April 3) and sponsored by the Genetics Society of America, the immunity and pathogenesis session comprised seven platform presentations and 34 posters that highlighted the latest advances in Drosophila infection and immunity field. The presented work covered a wide range of studies from immune signaling pathways and the molecular basis of humoral and cellular immune mechanisms to the role of endosymbionts in fly immune function and effects of immune priming. Here, we give an overview of the presented work and we explain how these findings will open new avenues in Drosophila immunity research.
果蝇已被确立为研究传染病的有用模型，因为它可以对大量完整动物进行研究，并提供强大的遗传工具，且在信号传导和发病机制方面与脊椎动物具有保守性。在过去二十年中，在果蝇针对各种致病生物的先天免疫反应的表征方面取得了重大进展（图1）。在今年于圣地亚哥举行（3月30日至4月3日）并由美国遗传学会主办的果蝇研究会议上，免疫与发病机制分会场包括七场平台报告和34篇海报展示，突出了果蝇感染与免疫领域的最新进展。所展示的工作涵盖了广泛的研究，从免疫信号通路、体液和细胞免疫机制的分子基础到共生菌在果蝇免疫功能中的作用以及免疫预激发的影响。在此，我们对所展示的工作进行概述，并解释这些发现将如何为果蝇免疫研究开辟新途径。
