Laboratory of Genes and Development, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Adv Genet. 2013;83:71-97. doi: 10.1016/B978-0-12-407675-4.00002-X.
Due to the evolutionary conservation of innate immune mechanisms, Drosophila has been extensively used as a model for the dissection in genetic terms of innate host immunity to infection. Genetic screening in fruit flies has set the stage for the pathways and systems required for responding to immune challenge and the dynamics of the progression of bacterial and fungal infection. In addition, fruit flies have been used as infection models to dissect host-pathogen interactions from both sides of this equation. This chapter describes our current understanding of the genetics of the fruit fly immune response and summarizes the most important findings in this area during the past decade.
由于先天免疫机制在进化上是保守的，因此果蝇被广泛用作研究宿主先天免疫对感染反应的遗传基础的模式生物。果蝇的遗传筛选为应对免疫挑战和细菌及真菌感染进展的动态所需的途径和系统奠定了基础。此外，果蝇还被用作感染模型，从这个等式的双方来剖析宿主-病原体相互作用。本章描述了我们目前对果蝇免疫反应的遗传学的理解，并总结了过去十年中这一领域的最重要发现。
