Parvez Babar, Emuwa Chinenye, Faulkner Marquetta L, Murray John J
Department of Internal Medicine, Meharry Medical College, 1818 Albion Street, Nashville, TN 37208, USA.
Case Rep Med. 2011;2011:729862. doi: 10.1155/2011/729862. Epub 2011 May 23.
Hypercalcemia is a relatively common clinical problem in both outpatient and inpatient settings. Primary pathophysiology is the entry of calcium that exceeds its excretion into urine or deposition in bone into circulation. Among a wide array of causes of hypercalcemia, hyperparathyroidism and malignancy are the most common, accounting for greater than 90 percent of cases. Concordantly, there has been a resurgence of milk-alkali syndrome associated with the ingestion of large amounts of calcium and absorbable alkali, making it the third leading cause of hypercalcemia (Beall and Scofield, 1995 and Picolos et al., 2005). This paper centers on a case of over-the-counter calcium and alkali ingestion for acid reflux leading to milk alkali with concordant use of thiazide diuretic for hypertension.
高钙血症在门诊和住院患者中都是相对常见的临床问题。主要病理生理学是钙进入血液循环的量超过其经尿液排泄或在骨骼中沉积的量。在众多导致高钙血症的原因中,甲状旁腺功能亢进和恶性肿瘤最为常见,占病例的90%以上。相应地,与大量摄入钙和可吸收碱相关的乳-碱综合征有所复发,使其成为高钙血症的第三大主要原因(比尔和斯科菲尔德,1995年;皮科洛斯等人,2005年)。本文聚焦于一例因胃食管反流而过量服用非处方钙和碱导致乳-碱综合征,并同时使用噻嗪类利尿剂治疗高血压的病例。