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重度抑郁症的抗抑郁治疗可能对自我不协调和自我协调的自杀意念产生不同影响。

Antidepressant therapy in severe depression may have different effects on ego-dystonic and ego-syntonic suicidal ideation.

作者信息

Brådvik Louise, Berglund Mats

机构信息

Division of Psychiatry, Department of Clinical Sciences Lund, Lund University Hospital, 221 85 Lund, Sweden.

出版信息

Depress Res Treat. 2011;2011:896395. doi: 10.1155/2011/896395. Epub 2011 May 12.

DOI:10.1155/2011/896395
PMID:21738871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3123969/
Abstract

The objective of the present study was to investigate whether ego-dystonic and ego-syntonic suicidal ideation occurred at different frequencies during antidepressant therapy. A blind evaluation has been performed on records of 100 suicides with a primary severe depression and 100 matched controls, admitted to the Department of Psychiatry, Lund, Sweden. Ego-dystonic suicidal ideation was more commonly reported during adequate treatment as compared to ego-syntonic ideation (P = .004). Men who committed suicide during adequate antidepressant therapy more often reported ego-dystonic suicidal ideation earlier in their lives compared with those who were not treated (P = .0377). This may indicate that treatment failure for ego-dystonic ideation was a precursor of their suicides. Consequently, ego-dystonic ideation seems to show a poorer response to antidepressant therapy as compared to ego-syntonic ideation, which may be more directly related to depression. Ego-dystonic ideation is proposed to be related to depressive psychosis.

摘要

本研究的目的是调查在抗抑郁治疗期间，自我不协调和自我协调的自杀观念是否以不同频率出现。对瑞典隆德精神病科收治的100例原发性重度抑郁症自杀患者和100例匹配对照的记录进行了盲法评估。与自我协调观念相比，在充分治疗期间，自我不协调自杀观念的报告更为常见（P = 0.004）。与未接受治疗的男性相比，在充分抗抑郁治疗期间自杀的男性在生命早期更常报告自我不协调自杀观念（P = 0.0377）。这可能表明自我不协调观念的治疗失败是他们自杀的先兆。因此，与自我协调观念相比，自我不协调观念似乎对抗抑郁治疗的反应较差，而自我协调观念可能与抑郁症更直接相关。自我不协调观念被认为与抑郁性精神病有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/4695aef0e54e/DRT2011-896395.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/520fbffb88d1/DRT2011-896395.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/97c00f88fa0b/DRT2011-896395.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/4695aef0e54e/DRT2011-896395.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/520fbffb88d1/DRT2011-896395.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/97c00f88fa0b/DRT2011-896395.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d179/3123969/4695aef0e54e/DRT2011-896395.003.jpg

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