Federal University of Paraná (UFPR).
Braz J Otorhinolaryngol. 2011 Jun;77(3):315-21. doi: 10.1590/s1808-86942011000300008.
Prospective experimental study in which we created a bony defect in the mastoids of rats and filled it up with hydroxyapatite to evaluate bone regeneration, to solve the problems of open cavities after mastoidectomies that frequently present with otorrhea, infection, granulation tissue and hearing loss.
The aim was to evaluate bone regeneration in defects created in the mastoids of rats, using hydroxyapatite, to see how much of the cavity we could reduce.
Twelve rats Wistar-Furth were used. A 0.5 x 0.5 cm bone defect was created in both temporal bones of the rats, and filled with 15 micrograms of hydroxyapatite. The left side was used as control. The animals were slaughtered 40 days afterwards and histology analyses were carried out.
In the hydroxyapatite group, the new bone growth involved an area of 68.53% of the total; and in the control group it was only of 15.97%.
It was observed a very good hydroxyapatite integration to the temporal bone in this experimental model. The microscopic results were superior with the use of hydroxyapatite when compared to the control group. It is a safe method and easy to apply to solve the problems of open cavities with chronic discharge and difficult to clean.
我们在大鼠的乳突中创建了一个骨质缺损，并填入羟基磷灰石，以评估骨再生，解决乳突切除术后经常出现的耳漏、感染、肉芽组织和听力损失等开放性空腔问题。
使用羟基磷灰石评估大鼠乳突中创建的缺陷处的骨再生情况，以了解我们可以减少多少空腔。
使用 12 只 Wistar-Furth 大鼠。在大鼠的双侧颞骨中创建 0.5 x 0.5 厘米的骨缺损，并填充 15 微克的羟基磷灰石。左侧作为对照。40 天后将动物处死并进行组织学分析。
在羟基磷灰石组中，新骨生长占总面积的 68.53%；而在对照组中仅为 15.97%。
在这个实验模型中，观察到羟基磷灰石与颞骨的非常好的整合。与对照组相比，使用羟基磷灰石的微观结果更好。这是一种安全且易于应用的方法，可解决慢性排液和难以清洁的开放性空腔问题。
