Department of Neurosurgery, S. Maria della Misericordia Hospital, Rovigo, Italy.
Neurochem Res. 2011 Nov;36(11):2145-54. doi: 10.1007/s11064-011-0539-6. Epub 2011 Jul 8.
The prognosis of patients affected by glioblastoma remains dismal despite many efforts have been devoted worldwide in research and therapeutic strategies. Reasons of our failure include the fact that the patient harboring a glioblastoma always has two problems inside the brain, the bulk tumor and the parenchyma microinfiltrated; the other reason is that the tumor is able to grow dynamically adapting to the mutated conditions of its growth microenvironment. This paper tries to give an interpretation to the dynamic process of the tumor growth, from the beginning to the end of its natural history, dividing it in three phases, one pre-hypoxia and two post-hypoxia, and these are then correlated with the types of cancer stem cells (CSCs) involved. Furthermore, the paper proposes an original animal model to follow glioblastoma development in only one generation of mice, both in the bulk and in the brain parenchyma.
尽管全世界在研究和治疗策略方面都做出了很多努力，胶质母细胞瘤患者的预后仍然不容乐观。我们失败的原因包括以下事实：患有胶质母细胞瘤的患者大脑内始终存在两个问题，即实体瘤和实质微浸润；另一个原因是肿瘤能够动态生长，以适应其生长微环境的突变条件。本文试图从肿瘤自然史的开始到结束，将其分为三个阶段，即缺氧前、缺氧后两个阶段，并将其与涉及的癌症干细胞（CSC）类型相关联，对肿瘤生长的动态过程进行解释。此外，本文提出了一种原始的动物模型，仅在一代小鼠中就可以同时在实体瘤和脑实质中观察到胶质母细胞瘤的发展。
