Choudat D, Frisch C, Barrat G, el Kholti A, Conso F
Département de médicine du travail, Faculté Cochin-Port-Royal, Paris France.
Br J Ind Med. 1990 Nov;47(11):763-6. doi: 10.1136/oem.47.11.763.
Respiratory manifestations among 41 workers exposed to amorphous silica dust were compared with a control group comprising 90 workers of equivalent socioeconomic state in the same plant. Flow volumes were determined, blood gas concentrations were measured at rest and during exercise, chest radiographs were obtained, and data about respiratory symptoms were collected by questionnaire. A dust exposure index was calculated for each exposed worker. It was not possible to differentiate between the two groups from the questionnaire, blood gas analysis, or chest radiographs. On the other hand, the tests of respiratory function showed a significant decrease in forced expiratory flow (FEF25-75, FEF50, and FEF75) in the exposed group compared with the controls, although no correlation was found between the exposure index and pulmonary function. It appears that smoking and exposure to amorphous silica synergise to induce small airway disease.
将41名接触无定形二氧化硅粉尘的工人的呼吸表现与同一工厂中90名社会经济状况相当的工人组成的对照组进行了比较。测定了流量，在静息和运动期间测量了血气浓度，拍摄了胸部X光片，并通过问卷调查收集了有关呼吸症状的数据。为每名接触粉尘的工人计算了粉尘暴露指数。从问卷调查、血气分析或胸部X光片无法区分两组。另一方面，呼吸功能测试显示，与对照组相比，接触组的用力呼气流量（FEF25-75、FEF50和FEF75）显著降低，尽管暴露指数与肺功能之间未发现相关性。似乎吸烟和接触无定形二氧化硅协同作用会诱发小气道疾病。
