Hudson R W, Lochnan H A, Danby F W, Margesson L J, Strang B K, Kimmett S M
Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Fertil Steril. 1990 Dec;54(6):1065-71.
To assess the role of the adrenal glands in the development of hirsutism, levels of 11 beta-hydroxyandrostenedione (11 beta-OHA), 17 alpha-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulphate (DHEAS), androstenedione (delta 4A), and free and total testosterone (T) were measured in 63 hirsute females and 30 control patients. Six of the hirsute patients had basal levels of 11 beta-OHA and 17-OHP and responses to adrenocorticotropic hormone that were significantly greater than these values in controls and the other hirsute women. These women were designated as having an adrenal source for their hirsutism. Women with polycystic ovarian syndrome and idiopathic hirsutism had normal values of 11 beta-OHA and 17-OHP. Levels of total and free T, DHEAS and delta 4A were significantly higher than control values in all of the hirsute women. This study demonstrates that 11 beta-OHA can be used as a marker to assess the adrenal contribution to hirsutism.
为评估肾上腺在多毛症发生发展中的作用，对63例多毛女性和30例对照患者测定了11β-羟雄烯二酮（11β-OHA）、17α-羟孕酮（17-OHP）、硫酸脱氢表雄酮（DHEAS）、雄烯二酮（δ4A）以及游离睾酮和总睾酮（T）的水平。6例多毛患者的11β-OHA和17-OHP基础水平以及对促肾上腺皮质激素的反应显著高于对照组和其他多毛女性。这些女性被认定为其多毛症源于肾上腺。多囊卵巢综合征和特发性多毛症女性的11β-OHA和17-OHP值正常。所有多毛女性的总睾酮和游离睾酮、DHEAS及δ4A水平均显著高于对照值。本研究表明，11β-OHA可作为评估肾上腺对多毛症影响的标志物。
