Mihu Dan, Sabău Lavinia, Costin Nicolae, Ciortea Răzvan, Măluţan Andrei, Mihu Carmen Mihaela
Department of Obstetrics-Gynecology II, Cluj-Napoca , Romania.
J Matern Fetal Neonatal Med. 2012 Jul;25(7):944-51. doi: 10.3109/14767058.2011.600796. Epub 2011 Aug 16.
To evaluate the intensity of oxidative stress in normal pregnancy and in pregnancy complicated by preeclampsia. To investigate a possible correlation between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth.
A retrospective transversal study was performed in three groups of 80 patients each: Group I--preeclampsia; Group II--normal pregnancy; Group III--control (non-pregnant patients). Degradation products of reactive oxygen species (lipid peroxides and protein carbonyls) and some antioxidants (hydrogen donor capacity and ceruloplasmin) were determined in the serum of patients. The data obtained were processed by descriptive and comparative statistical methods.
A moderate level of oxidative stress was found in normal pregnancy. We found statistically significant differences between the control group and the normal pregnancy group (p < 0.000). In preeclampsia, oxidative stress increases. Statistically significant differences were found in the evaluated parameters between the normal pregnancy group and the preeclampsia group (p < 0.000). There were no correlations between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth in the group with preeclampsia.
Oxidative stress in preeclampsia is the result of the increase in reactive oxygen species and of the decrease in antioxidants.
评估正常妊娠及合并子痫前期妊娠时氧化应激的强度。研究氧化应激强度、子痫前期严重程度与出生时胎儿状况之间可能存在的相关性。
对三组各80例患者进行回顾性横断面研究：第一组——子痫前期；第二组——正常妊娠；第三组——对照组（非妊娠患者）。测定患者血清中活性氧的降解产物（脂质过氧化物和蛋白质羰基）以及一些抗氧化剂（氢供体能力和铜蓝蛋白）。所得数据采用描述性和比较性统计方法进行处理。
正常妊娠时发现氧化应激处于中等水平。我们发现对照组与正常妊娠组之间存在统计学显著差异（p < 0.000）。子痫前期时，氧化应激增加。正常妊娠组与子痫前期组在评估参数上存在统计学显著差异（p < 0.000）。子痫前期组中氧化应激强度、子痫前期严重程度与出生时胎儿状况之间无相关性。
子痫前期的氧化应激是活性氧增加和抗氧化剂减少的结果。
