Division of Research, Hospital of Obstetrics and Gynecology at Western Medical Center, Mexican Institute of Social Security, Josefa Ortiz de Domínguez # 3694, Int 2. Colonia Yáñez, 44770 Guadalajara, Jalisco, México.
Arch Gynecol Obstet. 2011 Mar;283(3):415-22. doi: 10.1007/s00404-010-1753-1. Epub 2010 Nov 13.
Overweight is associated with alterations in lipid concentrations and an activation of inflammatory markers and both of these metabolic abnormalities are characteristic of preeclamptic pregnancies before the onset of clinically evident disease. Reactive oxygen species, particularly superoxide anions, evoke endothelial cell activation through many pathways. Markers of lipid peroxidation, including malondialdehyde and 8-epiprostaglandin-F2α, is increased in the plasma of women with preeclampsia, and the low concentrations of water- and lipid-soluble antioxidants in the plasma and the placenta further suggest a state of oxidative stress. This review focuses in the relation between maternal obesity, oxidative stress with development of preeclampsia.
超重与血脂浓度的改变以及炎症标志物的激活有关，而这两种代谢异常都是子痫前期在出现临床明显疾病之前的特征。活性氧，特别是超氧阴离子，通过多种途径引起内皮细胞激活。子痫前期妇女血浆中脂质过氧化的标志物，包括丙二醛和 8-epi 前列腺素 F2α，增加，而血浆和胎盘中水和脂溶性抗氧化剂的低浓度进一步表明存在氧化应激状态。这篇综述集中讨论了母体肥胖、氧化应激与子痫前期发展之间的关系。
