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[血管升压药和正性肌力药:在儿科中的应用]

[Vasopressors and inotropes: use in paediatrics].

作者信息

García-Canales Adrián, Peña-Juárez Rocío Alejandra, Sandoval-Franco Luz de María

机构信息

Departamento de Terapia Intensiva Pediátrica, Hospital Regional Valentín Gómez Farías, ISSSTE, Zapopan, Jalisco, México.

Departamento de Cardiología Pediátrica, Hospital General de Occidente, Zapopan, Jalisco, México.

出版信息

Arch Cardiol Mex. 2018 Jan-Mar;88(1):39-50. doi: 10.1016/j.acmx.2017.02.005. Epub 2017 Mar 21.

Abstract

The cardiovascular system is a dynamic system, which is required to ensure adequate delivery of oxygen, nutrients, and hormones to the tissues that are necessary for cell metabolism. It also synthesises and modifies the vasoactive components that regulate vascular tone and myocardial function. These vasoactive components have demonstrated their beneficial effects in the management of paediatric patients in a critical condition with heart failure and shock. However, their use and abuse brings harmful effects, increases mortality, and is associated with arrhythmias. An increase in myocardial oxygen consumption favours the presence of ischaemia, therefore it is necessary to know the mechanism of action and indications of these drugs to minimise their harmful effects. The purpose of this review is to describe the pharmacology and clinical applications of inotropic and vasopressor agents in the paediatric patient in acritical condition.

摘要

心血管系统是一个动态系统,需要确保向细胞代谢所需的组织充分输送氧气、营养物质和激素。它还合成和修饰调节血管张力和心肌功能的血管活性成分。这些血管活性成分已在治疗患有心力衰竭和休克的危重症儿科患者中显示出有益效果。然而,它们的使用和滥用会带来有害影响,增加死亡率,并与心律失常有关。心肌耗氧量增加有利于缺血的发生,因此有必要了解这些药物的作用机制和适应证,以尽量减少其有害影响。本综述的目的是描述强心剂和血管升压药在危重症儿科患者中的药理学和临床应用。

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