Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, Shandong 250012, China.
Chin Med J (Engl). 2011 Jun;124(11):1639-46.
Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to identify key areas in endemic areas of HFRS for future public health planning and resource allocation.
Rodent sampling was conducted in seven villages in Junan county from February 2006 to January 2007 using field epidemiological surveillance. Dynamics of hantavirus infection and population densities in rodents were investigated. Spatial statistical techniques including Ripley' L index and nearest neighbour hierarchical (NNH) clustering analysis were conducted to reveal the spatial structure of rodent populations in seven villages. Phylogenetic analysis and two-dimensional minimal spanning tree (2-D MST) models were employed to describe the spatial relationship of hantavirus strains.
Data showed that Mus musculus was the most common species in our study area, followed by Rattus norvegicus. Ripley's L index and NNH analysis showed that the spatial distribution of all captured rodents, Mus musculus and Rattus norvegicus in seven villages were clustered and there were hotspot areas of rodent distribution. The branches of 2-D MSTs had similar topologies to those of corresponding phylogenetic trees, and hantavirus strains exhibited obvious connective traces in seven villages.
These results contribute to the understanding of the spatial distribution of rodent populations and hantavirus infection patterns in small areas, and identify priority areas within the epidemic areas for the development of a better prevention strategy against hemorrhagic fever with renal syndrome in a small ecological area.
肾综合征出血热（HFRS）在中国山东省莒南县流行。我们进行了基于地理信息系统（GIS）的空间分析，旨在估计鼠群的空间分布及其汉坦病毒感染模式，描述小生态区域汉坦病毒株的空间关系，并确定 HFRS 流行地区的重点区域，以便为未来的公共卫生规划和资源分配提供参考。
2006 年 2 月至 2007 年 1 月，我们采用现场流行病学监测方法，在莒南县的 7 个村庄进行了鼠类采样。调查了鼠类汉坦病毒感染和种群密度的动态变化。采用 Ripley'L 指数和最近邻层次（NNH）聚类分析等空间统计技术，揭示 7 个村庄鼠类种群的空间结构。采用系统发育分析和二维最小生成树（2-D MST）模型，描述汉坦病毒株的空间关系。
数据显示，在我们的研究区域中，最常见的物种是小家鼠，其次是褐家鼠。Ripley'L 指数和 NNH 分析表明，所有捕获的鼠类、小家鼠和褐家鼠在 7 个村庄的空间分布呈聚集性，存在鼠类分布的热点区域。2-D MST 的分支与相应的系统发育树具有相似的拓扑结构，汉坦病毒株在 7 个村庄中表现出明显的连接痕迹。
这些结果有助于了解小区域内鼠类种群和汉坦病毒感染模式的空间分布，并确定流行地区内的优先区域，以便在小生态区域制定更好的肾综合征出血热防治策略。
