Hebei Key Laboratory of Pathogens and Epidemiology of Infectious Diseases, Institute for Viral Disease Control and Prevention, Hebei Provincial Center for Disease Control and Prevention, 97 Huaian East Road, Shijiazhuang, 050021, Hebei, China.
BMC Infect Dis. 2019 Sep 2;19(1):765. doi: 10.1186/s12879-019-4402-8.
Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic infectious disease caused by hantaviruses which circulate worldwide. So far, it was still considered as one of serious public health problems in China. The present study aimed to reveal the stabilities and variations of hantavirus infection in Hebei province located in North China through a long-term retrospective observation.
The epidemiological data of HFRS cases from all 11 cities of Hebei province since 1981 through 2016 were collected and descriptively analyzed. The rodent densities, species compositions and virus-carrying rates of different regions were collected from six separated rodent surveillance points which set up since 2007. The molecular diversity and phylogenetic relationship of hantaviruses circulating among rodents were analyzed based on partial viral glycoprotein gene.
HFRS cases have been reported every year in Hebei province, since the first local case was identified in 1981. The epidemic history can be artificially divided into three phases and a total of 55,507 HFRS cases with 374 deaths were reported during 1981-2016. The gender and occupational factors of susceptible population were invarible throughout, however age of that was gradually aging. The annual outbreak peak always present in spring, while the main epidemic region had gradully altered from south to northeast. Surveillance of rodents revealed that residential rodents significantly possessed higher density and virus-carring rate than field rodents. The house rat, Rattus norvegicus, was the dominant rodent species and Seoul virus S3 sub-genotype which is continued but slightly evolving perhaps to be the sole pathogen for local HFRS cases of Hebei province.
This long-term province-wide surveillance and epidemiological analysis has revealed the stabilities and variations of hantavirus infection in North China. In order to improve current prevention and control strategies of HFRS in China, all surveillance should be continuously enhanced and variations should be paid more attentions.
肾综合征出血热（HFRS）是一种由汉坦病毒引起的新发人畜共患传染病，在全球范围内流行。到目前为止，它仍被认为是中国严重的公共卫生问题之一。本研究旨在通过长期回顾性观察，揭示中国北方河北省汉坦病毒感染的稳定性和变化。
收集河北省自 1981 年至 2016 年 11 个城市的 HFRS 病例的流行病学数据，并进行描述性分析。从 2007 年设立的六个独立的鼠类监测点收集不同地区的鼠密度、种类组成和带病毒率。基于部分病毒糖蛋白基因分析流行于鼠类中的汉坦病毒的分子多样性和系统进化关系。
河北省自 1981 年首例本地病例报告以来，每年均有 HFRS 病例报告。该流行史可人为分为三个阶段，1981 年至 2016 年共报告 55507 例 HFRS 病例，死亡 374 例。易感人群的性别和职业因素始终不变，但年龄逐渐老化。每年的暴发高峰总是出现在春季，而主要的流行区域逐渐从南部向东北部转移。对鼠类的监测表明，居民区鼠类的密度和带病毒率明显高于野外鼠类。家鼠、褐家鼠是主要的鼠种，汉城病毒 S3 亚基因型可能是河北省当地 HFRS 病例的唯一病原体，它在不断进化但略有变化。
本研究对全省范围内的长期监测和流行病学分析揭示了华北地区汉坦病毒感染的稳定性和变化。为了改进中国目前肾综合征出血热的防控策略，应持续加强所有监测，并更加关注变化。
