Dicle University, Faculty of Science, Chemistry Department, 21280 Diyarbakır, Turkey.
Food Chem Toxicol. 2011 Sep;49(9):2433-8. doi: 10.1016/j.fct.2011.06.064. Epub 2011 Jun 28.
The present study was designed to evaluate the effect of Diyarbakır watermelon (Citrullus lanatus cv. Sürme) juice on lipid peroxidation states in rat liver, kidney and brain. In vivo administration of carbon tetrachloride (CCl(4)) once a week for 28 days caused a significant elevation of serum markers of liver damage, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB) and decrease in albumin when compared to the control group. However, administration of carbon tetrachloride along with watermelon juice or ursodeoxycolic acid (UDCA) significantly reduces these changes. Increased lipid peroxide (LPO) level was observed in the liver, kidney and brain tissues after CCl(4) administration. However, watermelon juice and UDCA treatment prevented the increase in LPO. The results indicated that watermelon juice protects the liver, kidney and brain tissues from experimental CCl(4) toxicity in rats and that the protective effect of watermelon juice may be due to its antioxidant activity and inhibition of lipid peroxide formation. In conclusion, present study reveals biological evidence that supports the use of watermelon juice in the treatment of chemical-induced hepatotoxicity.
本研究旨在评估迪亚巴克尔西瓜（Citrullus lanatus cv. Sürme）汁对大鼠肝、肾和脑脂质过氧化状态的影响。体内每周一次给予四氯化碳（CCl4）28 天，与对照组相比，血清肝损伤标志物天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、总胆红素（TB）显著升高，白蛋白降低。然而，与西瓜汁或熊去氧胆酸（UDCA）联合给予四氯化碳可显著减轻这些变化。CCl4 给药后，肝、肾和脑组织中脂质过氧化物（LPO）水平升高。然而，西瓜汁和 UDCA 处理可防止 LPO 的增加。结果表明，西瓜汁可保护大鼠肝、肾和脑组织免受实验性 CCl4 毒性，西瓜汁的保护作用可能与其抗氧化活性和抑制脂质过氧化物形成有关。总之，本研究提供了生物学证据，支持使用西瓜汁治疗化学诱导的肝毒性。
