Programa de Pós-Graduacão em Medicina, Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Neurosci Lett. 2011 Sep 20;502(3):143-6. doi: 10.1016/j.neulet.2011.06.042. Epub 2011 Jun 29.
Schizophrenia (SZ) is a chronic severe mental disorder. Increased inflammatory processes have been shown in acute and chronic SZ. Apoptotic processes may alter the neuronal network and are involved in the pathogenesis of several neurodegenerative diseases, such as SZ. Annexin-V seems to have a role on inhibition of pro-inflammatory activities during apoptosis. Tumor necrosis factor (TNF-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines which stimulate acute phase reactions. A chronic immune activation in SZ has been shown. The aim of this study was to compare annexin-V and TNF-alpha serum levels in chronic medicated patients with SZ and healthy controls. Thirty-eight outpatients from the HCPA Schizophrenia Program and 38 healthy controls were enrolled to this study protocol. Annexin-V and TNF-alpha serum levels were measured with ELISA. Serum annexin-V levels were significantly higher in patients with SZ than in controls (p<0.001) and TNF-alpha significantly lower (p<0.001). The present result of increased annexin-V and decreased serum levels of TNF-alpha compared to controls may be a result of the stabilization phase of psychosis and a reduction in metabolic brain aggression. In this complex picture, increased levels of annexin-V and decreased levels of TNF-alpha in our sample would be explained by illness stability and chronic treatment. Our findings support the hypothesis of a state dependant process of inflammation in SZ. Further prospective studies to clarify the findings described in this paper are needed.
精神分裂症（SZ）是一种慢性严重的精神障碍。已经表明，急性和慢性 SZ 中存在炎症过程增加。凋亡过程可能改变神经元网络，并参与几种神经退行性疾病的发病机制，如 SZ。膜联蛋白-V 在凋亡过程中抑制促炎活性方面似乎具有作用。肿瘤坏死因子（TNF-α）是一种参与全身炎症的细胞因子，是刺激急性期反应的细胞因子群的成员。已经表明 SZ 中存在慢性免疫激活。本研究的目的是比较慢性用药的 SZ 患者和健康对照者的血清膜联蛋白-V 和 TNF-α 水平。该研究方案纳入了来自 HCPA 精神分裂症计划的 38 名门诊患者和 38 名健康对照者。使用 ELISA 测量血清膜联蛋白-V 和 TNF-α 水平。与对照组相比，SZ 患者的血清膜联蛋白-V 水平显著升高（p<0.001），TNF-α 水平显著降低（p<0.001）。与对照组相比，本研究中增加的膜联蛋白-V 和降低的 TNF-α 血清水平可能是精神病稳定期和代谢性大脑攻击减少的结果。在这种复杂的情况下，我们样本中膜联蛋白-V 水平升高和 TNF-α 水平降低可以通过疾病稳定和慢性治疗来解释。我们的发现支持 SZ 中炎症状态依赖过程的假设。需要进一步的前瞻性研究来阐明本文所述的发现。
