Lv Bokun, Huang Jie, Yuan Haining, Yan Wenying, Hu Guang, Wang Jian
Systems Sepsis Team, Soochow University Affiliated Children's Hospital, Suzhou 215003, China ; Center for Systems Biology, Soochow University, Suzhou 215006, China.
Systems Sepsis Team, Soochow University Affiliated Children's Hospital, Suzhou 215003, China.
ScientificWorldJournal. 2014 Feb 11;2014:471463. doi: 10.1155/2014/471463. eCollection 2014.
Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α ) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013. Accordingly, 347 studies were collected totally, in which 15 articles and 23 trials were selected to study the NS in our meta-analysis. The TNF-α test showed moderate accuracy of the diagnosis of NS both in early-onset neonatal sepsis (sensitivity = 0.66, specificity = 0.76, Q∗ = 0.74) and in late-onset neonatal sepsis (sensitivity = 0.68, specificity = 0.89, Q∗ = 0.87). We also found the northern hemisphere group in the test has higher sensitivity (0.84) and specificity (0.83). A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity. Accordingly, we suggest that TNF-α is also a valuable marker in the diagnosis of NS.
新生儿败血症（NS）是新生儿死亡的重要原因，也是婴儿危及生命的疾病。进行荟萃分析以研究肿瘤坏死因子-α（TNF-α）检测在NS中的诊断价值。我们从1994年3月至2013年8月期间在PUBMED、EMBASE和Cochrane图书馆中检索了可收集的研究。因此，共收集到347项研究，其中15篇文章和23项试验被选入我们的荟萃分析以研究NS。TNF-α检测在早发型新生儿败血症（敏感性=0.66，特异性=0.76，Q*=0.74）和晚发型新生儿败血症（敏感性=0.68，特异性=0.89，Q*=0.87）中均显示出对NS诊断的中等准确性。我们还发现检测中的北半球组具有更高的敏感性（0.84）和特异性（0.83）。诊断性OR分析发现研究人群可能是异质性的主要原因。因此，我们认为TNF-α也是NS诊断中的一个有价值的标志物。
