Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
Acta Biomater. 2011 Oct;7(10):3638-44. doi: 10.1016/j.actbio.2011.06.029. Epub 2011 Jun 26.
Mg-, Zn- and Sr-doped hierarchically macroporous and mesoporous CaO-MO-SiO(2)-P(2)O(5) (M=Mg, Zn or Sr) bioactive glass (HMMBG) scaffolds were synthesized using the non-ionic block copolymer EO(20)PO(70)EO(20) and polyurethane sponges as cotemplates. The Mg-, Zn- or Sr-doped HMMBG scaffolds showed no distinct difference in phase composition, macroporous structure or pore volume from the HMMBG scaffolds without Mg, Zn or Sr. The Mg-, Zn- and Sr-doped HMMBG scaffolds showed no cytotoxicity. The gradual release of Ca, P, Si, Mg, Zn and Sr into the culture medium from these scaffolds contributed to the enhancement of the proliferation and ALP activity of mesenchymal stem cells (MSCs). The Mg-, Zn- and Sr-doped HMMBG scaffolds may be used as bone substitute materials.
采用非离子嵌段共聚物 EO(20)PO(70)EO(20)和聚氨酯海绵作为共模板，合成了 Mg、Zn 和 Sr 掺杂的分级大孔和介孔 CaO-MO-SiO(2)-P(2)O(5)（M=Mg、Zn 或 Sr）生物活性玻璃（HMMBG）支架。与不含 Mg、Zn 或 Sr 的 HMMBG 支架相比，Mg、Zn 或 Sr 掺杂的 HMMBG 支架在相组成、大孔结构和孔体积方面没有明显差异。Mg、Zn 和 Sr 掺杂的 HMMBG 支架无细胞毒性。这些支架中 Ca、P、Si、Mg、Zn 和 Sr 逐渐释放到培养基中，促进间充质干细胞（MSCs）的增殖和 ALP 活性。Mg、Zn 和 Sr 掺杂的 HMMBG 支架可用作骨替代材料。
