Department of Medicine, Recanati Miller Transplant Institute and Immunology Institute, Mount Sinai School of Medicine, New York, USA.
Immunobiology. 2012 Feb;217(2):216-24. doi: 10.1016/j.imbio.2011.06.004. Epub 2011 Jul 13.
Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immune modulation during a T cell response.
我们对补体系统的理解已经显著发展，从早期仅仅作为一个检测和标记病原体以进行进一步清除的蛋白质系统开始。例如，补体识别的危险信号谱目前涵盖了广泛的独特的自身和非自身危险信号。此外，补体现在已被确定为适应性 B 和 T 细胞免疫的指导者。这篇综述集中讨论了该领域最近出现的两个新范例。首先，补体不仅对于 Th1 免疫的诱导至关重要，而且对于这种保护性反应的及时收缩，从而预防自身免疫和免疫稳态也是至关重要的。其次，局部而不是系统补体影响 T 细胞反应期间的免疫调节。
