MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom.
Department of Epidemiology and Biostatistics, MedStar Health Research Institute, Hyattsville, Maryland.
J Ren Nutr. 2012 Mar;22(2):221-227. doi: 10.1053/j.jrn.2011.03.003. Epub 2011 Jul 13.
The present study examined the association between fish consumption and nephropathy in American Indians.
In the family cohort of the Strong Heart Study, we investigated 2,261 participants with baseline examination between 2001 and 2003 and follow-up examination between 2006 and 2008. The average follow-up period was 5.4 years. We defined fish consumption as the sum of dietary intake of tuna, fried fish, and nonfried fish obtained from a validated food frequency questionnaire. Nephropathy was defined as microalbuminuria (urinary albumin-creatinine ratio [ACR]: 30 to 299 mg/g), macroalbuminuria (urinary ACR: ≥ 300 mg/g), or an estimated glomerular filtration rate of <60 mL/min/1.73 m(2). Using regression models, we examined the association between fish consumption measured at baseline and 2 outcomes in nephropathy present at follow-up, albuminuria, or renal impairment, and change in urinary ACR or estimated glomerular filtration rate between baseline and follow-up examinations.
The prevalence of microalbuminuria, macroalbuminuria, and renal impairment was 13%, 3%, and 4%, respectively. The fish items consumed by the participants were predominantly deep-fried. We found no associations between fish consumption and any measure of nephropathy after adjusting for demographic, clinical, lifestyle, and dietary factors.
Dietary intake of predominantly fried fish was not associated with a lower risk of nephropathy in American Indians.
本研究旨在探讨美国印第安人群中鱼类摄入量与肾病之间的关联。
在“强壮心脏研究”的家族队列中，我们调查了 2261 名参与者，他们在 2001 年至 2003 年期间进行了基线检查，并在 2006 年至 2008 年期间进行了随访检查。平均随访期为 5.4 年。我们将鱼类摄入量定义为从经过验证的食物频率问卷中获得的金枪鱼、炸鱼和非炸鱼的饮食摄入量之和。肾病定义为微量白蛋白尿（尿白蛋白/肌酐比[ACR]：30 至 299mg/g）、大量白蛋白尿（尿 ACR：≥300mg/g）或估计肾小球滤过率<60mL/min/1.73m(2)。使用回归模型，我们检查了基线时测量的鱼类摄入量与随访时存在的肾病的 2 个结果（白蛋白尿或肾功能障碍）以及基线和随访检查之间尿 ACR 或估计肾小球滤过率的变化之间的关联。
微量白蛋白尿、大量白蛋白尿和肾功能障碍的患病率分别为 13%、3%和 4%。参与者食用的鱼类主要是油炸的。在调整人口统计学、临床、生活方式和饮食因素后，我们没有发现鱼类摄入量与肾病的任何衡量指标之间存在关联。
美国印第安人群中，主要食用油炸鱼的饮食摄入量与肾病风险降低无关。
