Department of Human Development and Family Studies, and Gerontology Center, Pennsylvania State University, University Park, USA.
J Gerontol B Psychol Sci Soc Sci. 2011 Jul;66 Suppl 1(Suppl 1):i71-81. doi: 10.1093/geronb/gbq094.
We examined associations between cognitive function (CF) and the naturally occurring daily cortisol levels using data from the Midlife in the United States survey and the National Study of Daily Experiences.
A national sample of 1,500 (mean age = 57 years; range = 33-84, 56% female) completed a phone-based battery of cognitive tasks and 3-6 months later provided saliva samples upon waking, 30 min after waking, at lunch time, and at bedtime on 4 consecutive days.
Higher CF, particularly executive function, was associated with healthier daily cortisol profiles, including a steeper diurnal cortisol slope, higher morning cortisol levels, and lower afternoon and evening cortisol levels.
The results indicate that better CF is associated with healthier profiles of naturally occurring cortisol and underscore the importance of the timing of cortisol sampling.
我们利用美国中年生活调查和国家日常经历研究的数据，研究认知功能（CF）与自然发生的日常皮质醇水平之间的关联。
一项全国性的 1500 人样本（平均年龄= 57 岁；范围= 33-84，56%为女性）完成了一项基于电话的认知任务组，并在 3-6 个月后在连续 4 天的早晨醒来、醒来后 30 分钟、午餐时间和睡前提供唾液样本。
较高的 CF，特别是执行功能，与更健康的日常皮质醇谱相关，包括更陡峭的日间皮质醇斜率、更高的早晨皮质醇水平以及更低的下午和晚上皮质醇水平。
结果表明，更好的 CF 与自然发生的皮质醇更健康的模式相关，并强调了皮质醇采样时间的重要性。
