Sin Nancy L, Ong Anthony D, Stawski Robert S, Almeida David M
Center for Healthy Aging, The Pennsylvania State University, United States; Department of Biobehavioral Health, The Pennsylvania State University, United States.
Department of Human Development, Cornell University, United States; Division of Geriatrics and Palliative Medicine, Weill Cornell Medical College, United States.
Psychoneuroendocrinology. 2017 Sep;83:91-100. doi: 10.1016/j.psyneuen.2017.06.001. Epub 2017 Jun 3.
Growing evidence from field studies has linked daily stressors to dysregulated patterns of diurnal cortisol. Less is known about whether naturally-occurring positive events in everyday life are associated with diurnal cortisol. The objectives of this study were to evaluate daily positive events as predictors of between-person differences and within-person (day-to-day) variations in diurnal cortisol parameters, in addition to daily positive events as buffers against the associations between daily stressors and cortisol. In the National Study of Daily Experiences, 1657 adults ages 33-84 (57% female) reported daily experiences during telephone interviews on 8 consecutive evenings. Saliva samples were collected 4 times per day on 4 interview days and assayed for cortisol. Multilevel models were used to estimate associations of daily positive events with cortisol awakening response (CAR), diurnal cortisol slope, and area under the curve (AUC). At the between-person level, people who experienced more frequent positive events exhibited a steeper diurnal cortisol slope, controlling for daily stressors, daily affect, and other covariates. At the within-person level, positive events in the morning (but not prior-night or afternoon/evening events) predicted steeper decline in cortisol across that day; positive events were also marginally associated with lower same-day AUC. Associations were not mediated by daily positive affect, and positive events did not buffer against stressor-related cortisol alterations. These findings indicate that individual differences and day-to-day variations in daily positive events are associated with diurnal cortisol patterns, independent of stressors and affect.
来自实地研究的越来越多的证据将日常压力源与昼夜皮质醇失调模式联系起来。对于日常生活中自然发生的积极事件是否与昼夜皮质醇有关,人们了解得较少。本研究的目的是评估日常积极事件作为昼夜皮质醇参数个体间差异和个体内(每日)变化的预测因素,以及日常积极事件作为日常压力源与皮质醇之间关联的缓冲因素。在全国日常经历研究中,1657名年龄在33 - 84岁之间的成年人(57%为女性)在连续8个晚上的电话访谈中报告了他们的日常经历。在4个访谈日中,每天收集4次唾液样本并检测皮质醇。使用多层次模型来估计日常积极事件与皮质醇觉醒反应(CAR)、昼夜皮质醇斜率和曲线下面积(AUC)之间的关联。在个体间水平上,在控制了日常压力源、日常情绪和其他协变量后,经历更频繁积极事件的人表现出更陡的昼夜皮质醇斜率。在个体内水平上,早晨的积极事件(而非前一晚或下午/晚上的事件)预测了当天皮质醇更陡的下降;积极事件也与同一天较低的AUC略有相关。这些关联并非由日常积极情绪介导,并且积极事件并未缓冲压力源相关的皮质醇变化。这些发现表明,日常积极事件的个体差异和每日变化与昼夜皮质醇模式相关,独立于压力源和情绪。