老年女性外周血单个核细胞中环核苷酸磷酸二酯酶活性降低。
Decreased cyclic nucleotide phosphodiesterase activity in human peripheral blood mononuclear cells from elderly women.
作者信息
Meskini N, Macovschi O, Prigent A F, Nemoz G, Chapuy P, Lagarde M
机构信息
Unité INSERM 205, Institut National des Sciences Appliquées, Villeurbanne, France.
出版信息
Clin Sci (Lond). 1990 Nov;79(5):467-70. doi: 10.1042/cs0790467.
PMID:2174313
Abstract
- Both adenosine 3':5'-cyclic monophosphate and guanosine 3':5'-cyclic monophosphate phosphodiesterase activities of peripheral blood mononuclear cells were markedly decreased in elderly women as compared with young control women. 2. In contrast, the ability of these cells to bind guanosine 5'-[beta, gamma-imido]triphosphate, a non-hydrolysable analogue of guanosine 5'-triphosphate, was the same in both groups. 3. These findings are discussed in the context of the decline in immune function which occurs with increasing age.
摘要
- 与年轻的对照女性相比，老年女性外周血单个核细胞的腺苷3':5'-环磷酸和鸟苷3':5'-环磷酸磷酸二酯酶活性均显著降低。2. 相比之下，这些细胞结合鸟苷5'-[β,γ-亚氨基]三磷酸（鸟苷5'-三磷酸的一种不可水解类似物）的能力在两组中是相同的。3. 这些发现是在随着年龄增长免疫功能下降的背景下进行讨论的。
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