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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Meskini N, Macovschi O, Prigent A F, Nemoz G, Chapuy P, Lagarde M

Unité INSERM 205, Institut National des Sciences Appliquées, Villeurbanne, France.

Clin Sci (Lond). 1990 Nov;79(5):467-70. doi: 10.1042/cs0790467.

Both adenosine 3':5'-cyclic monophosphate and guanosine 3':5'-cyclic monophosphate phosphodiesterase activities of peripheral blood mononuclear cells were markedly decreased in elderly women as compared with young control women. 2. In contrast, the ability of these cells to bind guanosine 5'-[beta, gamma-imido]triphosphate, a non-hydrolysable analogue of guanosine 5'-triphosphate, was the same in both groups. 3. These findings are discussed in the context of the decline in immune function which occurs with increasing age.

与年轻的对照女性相比，老年女性外周血单个核细胞的腺苷3':5'-环磷酸和鸟苷3':5'-环磷酸磷酸二酯酶活性均显著降低。2. 相比之下，这些细胞结合鸟苷5'-[β,γ-亚氨基]三磷酸（鸟苷5'-三磷酸的一种不可水解类似物）的能力在两组中是相同的。3. 这些发现是在随着年龄增长免疫功能下降的背景下进行讨论的。

Meskini N, Macovschi O, Prigent A F, Nemoz G, Chapuy P, Lagarde M

Unité INSERM 205, Institut National des Sciences Appliquées, Villeurbanne, France.

Clin Sci (Lond). 1990 Nov;79(5):467-70. doi: 10.1042/cs0790467.

Both adenosine 3':5'-cyclic monophosphate and guanosine 3':5'-cyclic monophosphate phosphodiesterase activities of peripheral blood mononuclear cells were markedly decreased in elderly women as compared with young control women. 2. In contrast, the ability of these cells to bind guanosine 5'-[beta, gamma-imido]triphosphate, a non-hydrolysable analogue of guanosine 5'-triphosphate, was the same in both groups. 3. These findings are discussed in the context of the decline in immune function which occurs with increasing age.

与年轻的对照女性相比，老年女性外周血单个核细胞的腺苷3':5'-环磷酸和鸟苷3':5'-环磷酸磷酸二酯酶活性均显著降低。2. 相比之下，这些细胞结合鸟苷5'-[β,γ-亚氨基]三磷酸（鸟苷5'-三磷酸的一种不可水解类似物）的能力在两组中是相同的。3. 这些发现是在随着年龄增长免疫功能下降的背景下进行讨论的。