[贲门和胃底癌近端胃切除术与全胃切除术的荟萃分析]
[Meta-analysis of proximal gastrectomy and total gastrectomy for cancer of cardia and fundus].
作者信息
Ding Jie, Liao Guoqing, Yan Zhongshu, Liu Heli, Tang Jing, Liu Sheng, Liu Zhenqian, Wang Jiancai, Yan Shunli, Zhou Yi
机构信息
Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jun;36(6):570-5. doi: 10.3969/j.issn.1672-7347.2011.06.016.
OBJECTIVE
To assess the value of proximal gastrectomy (PG) and total gastrectomy (TG) for the treatment of cancer of cardia and fundus.
METHODS
Publications on comparision between PG and TG in the treatment of cancer of cardia and fundus were collected, the data from the publications were matched with the PG group and the TG group respectively according to its corresponding surgical resection, and the data on postoperative complications, motality and 5-year survival rate were meta-analyzed by fixed effect model and random effect model.
RESULTS
Thirteen reseaches on 2 219 patients were included in this study, 2 of which were randomly controlled studies. There were no significant differences in the postoperative complications (OR=1.00, 95%CI: 0.44-2.28,P>0.05) and mortality (OR=1.25, 95%CI: 0.62-2.48,P>0.05) between the PG group and the TG group, while there was significant difference in the 5-year survival rate (HR=0.87, 95%CI: 0.76-0.99,P=0.04). The 5-year survival rate in the TG group was higher than that in the PG group.
CONCLUSION
Total gastrectomy for the treatment of cancer of cardia and fundus has better long-term therapetic effect.
目的
评估近端胃切除术（PG）和全胃切除术（TG）治疗贲门癌和胃底癌的价值。
方法
收集关于PG与TG治疗贲门癌和胃底癌比较的文献，根据相应手术切除情况将文献数据分别与PG组和TG组匹配，采用固定效应模型和随机效应模型对术后并发症、死亡率及5年生存率数据进行Meta分析。
结果
本研究纳入13项针对2219例患者的研究，其中2项为随机对照研究。PG组与TG组术后并发症（OR = 1.00，95%CI：0.44 - 2.28，P>0.05）及死亡率（OR = 1.25，95%CI：0.62 - 2.48，P>0.05）差异均无统计学意义，而5年生存率差异有统计学意义（HR = 0.87，95%CI：0.76 - 0.99，P = 0.04），TG组5年生存率高于PG组。
结论
全胃切除术治疗贲门癌和胃底癌具有更好的长期治疗效果。
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