Akçay Adnan Burak, Camsarı Ahmet, Ozcan Türkay, Ciçek Dilek, Akkuş Necdet, Seyis Sabri, Cimen Burak, Celebi Barış, Döven Oben, Cin Gökhan
Department of Cardiology, Medicine Faculty of Mersin University, Mersin, Turkey.
Turk Kardiyol Dern Ars. 2011 Jul;39(5):371-7. doi: 10.5543/tkda.2011.01382.
We investigated the correlation of serum paraoxonase-1 (PON-1) activity with coronary artery disease (CAD) in patients with metabolic syndrome (MetS).
The study included 21 patients (mean age 55 ± 9 years) with MetS, stable angina pectoris, and angiographically shown CAD, 24 patients (mean age 51 ± 10 years) with MetS and angiographically normal coroner arteries, and 28 healthy controls (mean age 49 ± 12 years). Demographic and clinical characteristics, insulin levels, homeostasis model assessment of insulin resistance index, and PON-1 activity were assessed in all the groups. Severity of CAD was assessed using the Gensini score.
Paraoxonase-1 activity was significantly lower in patients with MetS compared to the control group (p=0.02). The two MetS groups with and without CAD exhibited similar characteristics in all the parameters including PON-1 activity (p>0.05). Univariate correlation analysis performed in MetS-CAD patients showed a significant negative correlation between the Gensini score and PON-1 activity (r=-0.48, p=0.02). The overall PON-1 activity of all the subjects showed no correlation with the parameters examined.
Decreased PON-1 activity in patients with MetS compared to the control group suggests increased oxidative stress in MetS. Detection of similar PON-1 activity levels in MetS groups with and without CAD suggests that disturbance of oxidative-antioxidative balance occurs before the development of CAD. The negative correlation between the Gensini score and PON-1 activity implies that decreased PON-1 activity may be one of the etiologic causes of atherosclerotic progress in MetS.
我们研究了代谢综合征（MetS）患者血清对氧磷酶-1（PON-1）活性与冠状动脉疾病（CAD）之间的相关性。
该研究纳入了21例患有MetS、稳定型心绞痛且血管造影显示患有CAD的患者（平均年龄55±9岁），24例患有MetS且血管造影显示冠状动脉正常的患者（平均年龄51±10岁），以及28名健康对照者（平均年龄49±12岁）。对所有组进行了人口统计学和临床特征、胰岛素水平、胰岛素抵抗指数的稳态模型评估以及PON-1活性评估。使用Gensini评分评估CAD的严重程度。
与对照组相比，MetS患者的对氧磷酶-1活性显著降低（p=0.02）。有CAD和无CAD的两个MetS组在包括PON-1活性在内的所有参数上表现出相似的特征（p>0.05）。对MetS-CAD患者进行的单变量相关性分析显示，Gensini评分与PON-1活性之间存在显著负相关（r=-0.48，p=0.02）。所有受试者的总体PON-1活性与所检查的参数均无相关性。
与对照组相比，MetS患者PON-1活性降低表明MetS中氧化应激增加。有CAD和无CAD的MetS组中PON-1活性水平相似，这表明氧化-抗氧化平衡的紊乱发生在CAD发展之前。Gensini评分与PON-1活性之间的负相关意味着PON-1活性降低可能是MetS中动脉粥样硬化进展的病因之一。
