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血清脂联素水平低与代谢综合征及血管造影确定的冠状动脉粥样硬化均独立相关。

Low serum adiponectin is independently associated with both the metabolic syndrome and angiographically determined coronary atherosclerosis.

作者信息

Saely Christoph H, Risch Lorenz, Hoefle Guenter, Rein Philipp, Muendlein Axel, Marte Thomas, Aczel Stefan, Langer Peter, Drexel Heinz

机构信息

Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Carinagasse 47, A-6800 Feldkirch, Austria.

出版信息

Clin Chim Acta. 2007 Aug;383(1-2):97-102. doi: 10.1016/j.cca.2007.04.029. Epub 2007 May 10.

DOI:10.1016/j.cca.2007.04.029
PMID:17550784
Abstract

BACKGROUND

We aimed at investigating serum adiponectin in patients with the metabolic syndrome (MetS), in patients with angiographically diagnosed coronary artery disease (CAD), and in patients who had both, the MetS and CAD.

METHODS

We enrolled 687 consecutive patients undergoing coronary angiography for the evaluation of CAD.

RESULTS

From our patients, 178 had neither the MetS (Adult Treatment Panel III definition) nor significant CAD (MetS-/CAD-), 91 had the MetS, but not significant CAD (MetS+/CAD-), 251 did not have the MetS but had significant CAD (MetS-/CAD+), and 167 had both, the MetS and significant CAD (MetS+/CAD+). Serum adiponectin was highest (12.1+/-8.3 microg/ml) in MetS-/CAD- subjects. It was significantly lower in MetS+/CAD- (9.5+/-7.3 microg/ml; p=0.001) and in MetS-/CAD+ patients (9.2+/-5.3 microg/ml; p<0.001) and lowest in MetS+/CAD+ patients (6.7+/-3.8 microg/ml) in whom it was significantly lower than in MetS-/CAD-, MetS+/CAD-, and MetS-/CAD+ patients (p<0.001 for all comparisons). In analysis of covariance the MetS and significant CAD proved associated with serum adiponectin in a mutually independent manner.

CONCLUSIONS

Low serum adiponectin is independently associated with both the MetS and coronary atherosclerosis.

摘要

背景

我们旨在研究代谢综合征（MetS）患者、经血管造影诊断为冠心病（CAD）的患者以及同时患有MetS和CAD的患者的血清脂联素水平。

方法

我们纳入了687例连续接受冠状动脉造影以评估CAD的患者。

结果

在我们的患者中，178例既无MetS（成人治疗小组III定义）也无显著CAD（MetS-/CAD-），91例有MetS但无显著CAD（MetS+/CAD-），251例无MetS但有显著CAD（MetS-/CAD+），167例同时患有MetS和显著CAD（MetS+/CAD+）。血清脂联素在MetS-/CAD-受试者中最高（12.1±8.3微克/毫升）。在MetS+/CAD-患者（9.5±7.3微克/毫升；p=0.001）和MetS-/CAD+患者（9.2±5.3微克/毫升；p<0.001）中显著降低，在MetS+/CAD+患者中最低（6.7±3.8微克/毫升），且显著低于MetS-/CAD-、MetS+/CAD-和MetS-/CAD+患者（所有比较p<0.001）。在协方差分析中，MetS和显著CAD被证明以相互独立的方式与血清脂联素相关。

结论

低血清脂联素与MetS和冠状动脉粥样硬化均独立相关。

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