Department of Haematology, Faculty of Medicine, Imperial College London, London, UK.
Bone Marrow Transplant. 2012 Apr;47(4):568-73. doi: 10.1038/bmt.2011.134. Epub 2011 Jul 11.
We have audited the invitation for uptake and outcome of artificial reproductive techniques in patients undergoing SCT for haematological malignancy, with the aim of improving our pre-transplant counselling. A postal survey was sent to 434 patients in our centre surviving a minimum of 2 years after allo-SCT, of whom 221 patients responded. Of 112 male patients, 79 were offered sperm storage, 42 banked sperm and 25 subsequently attempted parenthood with stored sperm. A total of 18 were successful, with 29 children born a median of 8 years (range 1-22 years) following SCT. Of 72 females <42 years old, 33 were offered storage of embryos/eggs/ovarian tissue and 12 accepted. Following SCT, four women attempted pregnancy using cryopreserved embryos, with two successes. The majority of patients who were not counselled about infertility or not offered fertility-preservation options provided a likely reason, with completion of family being the most frequent. Nonetheless, 16 patients (11/72 women and 5/112 men) could not provide a reason for the lack of information/invitation. In conclusion, uptake of gamete/embryo storage is high when offered and collected material is used frequently. Pregnancies in partners of male patients were usually successful and our data highlight the value of prolonged cryostorage.
我们已经审核了接受和实施人工生殖技术的邀请，以及血液病患者接受 SCT 的结果，旨在改善我们的移植前咨询。我们向中心内至少在 allo-SCT 后存活 2 年的 434 名患者发送了一份邮寄调查，其中 221 名患者做出了回应。在 112 名男性患者中，有 79 人接受了精子储存，42 人储存了精子，25 人随后尝试使用储存的精子生育。共有 18 人成功，29 个孩子在 SCT 后平均 8 年（范围 1-22 年）出生。在 72 名年龄<42 岁的女性中，有 33 人被建议储存胚胎/卵子/卵巢组织，其中 12 人接受了建议。在 SCT 之后，有 4 名女性使用冷冻胚胎尝试怀孕，其中 2 人成功。大多数未接受不孕咨询或未提供生育保护选择的患者提供了一个可能的原因，其中完成家庭是最常见的原因。尽管如此，仍有 16 名患者（11/72 名女性和 5/112 名男性）无法提供缺乏信息/邀请的原因。总之，当提供并收集配子/胚胎储存时，其接受度很高，并且经常使用储存的材料。男性患者伴侣的妊娠通常很成功，我们的数据强调了长期冷冻存储的价值。
