Anna Tharyan, MD, DPM, Lecture, Department of Psychiatry, Christian Medical College, Vellore - 632 002.
Indian J Psychiatry. 1994 Apr;36(2):74-8.
A depressive syndrome as identified by subjectively volunteered dysphoria occurred in 17.4% of a group of 45 DSM III-R schizophrenics, studied initially in a medication free state. Among the 24 patients who could be followed up for six months, another 25% developed depressive symptoms while on treatment. Mild depressive syndromes occurred more frequently in older patients, in association with retained insiglu and lower negative symptoms scores. While depressive symptoms occurred both in the medicated and unmedicated state, depressed medicated schizophrenics differed from non-depressed medicated schizophrenics on variables of total medication dosage, presence of extrapyramidal symptoms and insight.
一组 45 名符合 DSM III-R 精神分裂症诊断标准的患者在未用药状态下初步接受研究，其中 17.4%存在可主观报告的心境恶劣，表明存在抑郁综合征。在可随访 6 个月的 24 名患者中，又有 25%的患者在治疗过程中出现抑郁症状。轻度抑郁综合征在年龄较大的患者中更为常见，与胰岛素分泌不活跃和阴性症状评分较低有关。虽然抑郁症状既出现在用药状态，也出现在未用药状态，但在总用药剂量、锥体外系症状和洞察力等变量方面，抑郁用药精神分裂症患者与非抑郁用药精神分裂症患者存在差异。
