Ho David, Zhao Xin, Gao Shumin, Hong Chull, Vatner Dorothy E, Vatner Stephen F
The University of Medicine & Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey.
Curr Protoc Mouse Biol. 2011 Mar 1;1:123-139. doi: 10.1002/9780470942390.mo100159.
The majority of current cardiovascular research involves studies in genetically engineered mouse models. The measurement of heart rate is central to understanding cardiovascular control under normal conditions, with altered autonomic tone, superimposed stress or disease states, both in wild type mice as well as those with altered genes. Electrocardiography (ECG) is the "gold standard" using either hard wire or telemetry transmission. In addition, heart rate is measured or monitored from the frequency of the arterial pressure pulse or cardiac contraction, or by pulse oximetry. For each of these techniques, discussions of materials and methods, as well as advantages and limitations are covered. However, only the direct ECG monitoring will determine not only the precise heart rates but also whether the cardiac rhythm is normal or not.
目前大多数心血管研究都涉及对基因工程小鼠模型的研究。心率测量对于理解正常情况下、自主神经张力改变时、叠加应激或疾病状态下野生型小鼠以及基因改变小鼠的心血管控制至关重要。心电图（ECG）是使用硬线或遥测传输的“金标准”。此外，心率可通过动脉压脉搏或心脏收缩频率来测量或监测，也可通过脉搏血氧饱和度测定法来测量。对于这些技术中的每一种，都涵盖了材料和方法的讨论以及优缺点。然而，只有直接的心电图监测不仅能确定精确的心率，还能确定心律是否正常。
