小鼠的超声心动图检查
Echocardiography in Mice.
作者信息
Gao Shumin, Ho David, Vatner Dorothy E, Vatner Stephen F
机构信息
Department of Cell Biology & Molecular Medicine and The Cardiovascular Research Institute at the University of Medicine & Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, MSB G609, Newark, NJ 07103, USA.
出版信息
Curr Protoc Mouse Biol. 2011 Mar 1;1:71-83. doi: 10.1002/9780470942390.mo100130.
Abstract
Murine models have been utilized with increasing frequency mainly due to availability of genetically engineered models. With advancement in high spatial and temporal resolution, echocardiography is used extensively for the evaluation of cardiovascular function in murine models of cardiovascular disease. This review summarizes the general applications and methods involved in echocardiography used to study mouse models for cardiovascular research, based on 20 years of experience in our laboratory. The goal of this article is to provide a practical guide to the use of echo techniques in mice to evaluate cardiac systolic and diastolic function.
摘要
由于基因工程模型的可得性，小鼠模型的使用频率越来越高。随着高空间和时间分辨率技术的进步，超声心动图被广泛用于评估心血管疾病小鼠模型的心血管功能。基于我们实验室20年的经验，本综述总结了用于研究心血管疾病小鼠模型的超声心动图的一般应用和方法。本文的目的是提供一份实用指南，介绍在小鼠中使用超声技术评估心脏收缩和舒张功能的方法。
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Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H707-12. doi: 10.1152/ajpheart.00148.2010. Epub 2010 Jun 18.
2
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Circ Cardiovasc Imaging. 2008 Nov;1(3):227-34. doi: 10.1161/CIRCIMAGING.107.745919. Epub 2008 Sep 17.
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