非甲羟戊酸途径的生物化学。
Biochemistry of the non-mevalonate isoprenoid pathway.
机构信息
Department Chemie, Lehrstuhl für Biochemie, Center for Integrated Protein Science München, Technische Universität München, Garching, Germany.
出版信息
Cell Mol Life Sci. 2011 Dec;68(23):3797-814. doi: 10.1007/s00018-011-0753-z. Epub 2011 Jul 9.
Abstract
The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many eubacteria including the major human pathogen, Mycobacterium tuberculosis, in apicomplexan protozoa including the Plasmodium spp. causing malaria, and in the plastids of plants. The metabolic route is absent in humans and is therefore qualified as a promising target for new anti-infective drugs and herbicides. Biochemical and structural knowledge about all enzymes involved in the pathway established the basis for discovery and development of inhibitors by high-throughput screening of compound libraries and/or structure-based rational design.
摘要
异戊烯（萜烯）生物合成的非甲羟戊酸途径在许多真细菌中是必不可少的，包括主要的人类病原体结核分枝杆菌、顶复门原生动物包括引起疟疾的疟原虫，以及植物的质体。该代谢途径在人类中不存在，因此有资格成为新的抗感染药物和除草剂的有希望的靶标。关于该途径中所有酶的生化和结构知识为通过高通量筛选化合物文库和/或基于结构的合理设计发现和开发抑制剂奠定了基础。
相似文献
1
Biochemistry of the non-mevalonate isoprenoid pathway.非甲羟戊酸途径的生物化学。
Cell Mol Life Sci. 2011 Dec;68(23):3797-814. doi: 10.1007/s00018-011-0753-z. Epub 2011 Jul 9.
2
Isoprenoid biosynthetic pathways as anti-infective drug targets.类异戊二烯生物合成途径作为抗感染药物靶点。
Biochem Soc Trans. 2005 Aug;33(Pt 4):785-91. doi: 10.1042/BST0330785.
3
Biosynthesis of isoprenoids via the non-mevalonate pathway.通过非甲羟戊酸途径进行类异戊二烯的生物合成。
Cell Mol Life Sci. 2004 Jun;61(12):1401-26. doi: 10.1007/s00018-004-3381-z.
4
Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes.基于结构的靶向类异戊二烯生物合成的药物设计：相关酶的晶体学研究现状
Curr Protein Pept Sci. 2008 Apr;9(2):117-137. doi: 10.2174/138920308783955261.
5
The non-mevalonate isoprenoid biosynthesis of plants as a test system for new herbicides and drugs against pathogenic bacteria and the malaria parasite.植物的非甲羟戊酸类异戊二烯生物合成作为针对病原菌和疟原虫的新型除草剂及药物的测试系统。
Z Naturforsch C J Biosci. 2000 May-Jun;55(5-6):305-13. doi: 10.1515/znc-2000-5-601.
6
The isoprenoid-precursor dependence of Plasmodium spp.疟原虫属的异戊烯前体依赖性。
Nat Prod Rep. 2012 Jul;29(7):721-8. doi: 10.1039/c2np20013a. Epub 2012 May 4.
7
Metabolic plasticity for isoprenoid biosynthesis in bacteria.细菌中异戊烯基生物合成的代谢可塑性。
Biochem J. 2013 May 15;452(1):19-25. doi: 10.1042/BJ20121899.
8
The non-mevalonate pathway of isoprenoid precursor biosynthesis.类异戊二烯前体生物合成的非甲羟戊酸途径。
J Biol Chem. 2007 Jul 27;282(30):21573-7. doi: 10.1074/jbc.R700005200. Epub 2007 Apr 18.
9
A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.细胞代谢轮廓分析揭示抗疟和抗菌剂福米霉素的第二个作用靶点。
Biochemistry. 2011 May 3;50(17):3570-7. doi: 10.1021/bi200113y. Epub 2011 Apr 11.
10
Druggability of the enzymes of the non-mevalonate-pathway.非甲羟戊酸途径中酶的可成药性
Drug Discov Today. 2013 Dec;18(23-24):1256-62. doi: 10.1016/j.drudis.2013.07.003. Epub 2013 Jul 13.
引用本文的文献
1
Insights into chemistry, extraction and industrial application of lemon grass essential oil -A review of recent advances.柠檬草精油的化学、提取及工业应用研究进展——近期进展综述
Food Chem X. 2024 May 28;22:101521. doi: 10.1016/j.fochx.2024.101521. eCollection 2024 Jun 30.
2
Heterologous expression of and genes of var. is sufficient to produce 2-methylisoborneol in .铜绿微囊藻变种的和基因的异源表达足以在铜绿微囊藻中产生2-甲基异冰片。
Microbiol Spectr. 2023 Sep 21;11(5):e0256123. doi: 10.1128/spectrum.02561-23.
3
Vγ9Vδ2 T-cell immunotherapy in blood cancers: ready for prime time?γ9δ2 T 细胞免疫疗法治疗血液肿瘤：是否已准备好进入黄金时代？
Front Immunol. 2023 Apr 18;14:1167443. doi: 10.3389/fimmu.2023.1167443. eCollection 2023.
4
Metabolic Engineering for the Production of Lycopene.用于生产番茄红素的代谢工程。
Molecules. 2020 Jul 9;25(14):3136. doi: 10.3390/molecules25143136.
5
Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints.从进化印记解析疟原虫 IspD 同源物的结构、功能和机制。
J Comput Aided Mol Des. 2019 Apr;33(4):419-436. doi: 10.1007/s10822-019-00191-2. Epub 2019 Feb 19.
6
Synthesis and Kinetic evaluation of an azido analogue of methylerythritol phosphate: a Novel Inhibitor of E. coli YgbP/IspD.甲基赤藓醇磷酸合成酶及其类似物的合成与动力学评价：一种新型大肠杆菌 YgbP/IspD 的抑制剂。
Sci Rep. 2018 Dec 17;8(1):17892. doi: 10.1038/s41598-018-35586-y.
7
Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli.大肠杆菌生产异戊二烯和异戊烯醇的代谢工程。
Appl Microbiol Biotechnol. 2018 Sep;102(18):7725-7738. doi: 10.1007/s00253-018-9200-5. Epub 2018 Jul 14.
8
A Defective Undecaprenyl Pyrophosphate Synthase Induces Growth and Morphological Defects That Are Suppressed by Mutations in the Isoprenoid Pathway of Escherichia coli.缺陷型十一烯基焦磷酸合酶诱导的生长和形态缺陷可被大肠杆菌异戊烯基途径突变所抑制。
J Bacteriol. 2018 Aug 24;200(18). doi: 10.1128/JB.00255-18. Print 2018 Sep 15.
9
Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from .来自……的1-脱氧-D-木酮糖-5-磷酸合酶的机制研究 。 （原文中“from”后面缺少具体内容）
Biochem Mol Biol J. 2018;4(1). doi: 10.21767/2471-8084.100051. Epub 2018 Jan 29.
10
The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis.甲基赤藓糖醇磷酸途径：对抗结核病中颇具前景的药物靶点
ACS Infect Dis. 2018 Mar 9;4(3):278-290. doi: 10.1021/acsinfecdis.7b00176. Epub 2018 Feb 8.
本文引用的文献
1
Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus.嗜热栖热菌的E-1-羟基-2-甲基丁-2-烯基-4-二磷酸合酶（GcpE）的结构
FEBS Lett. 2011 Feb 4;585(3):447-51. doi: 10.1016/j.febslet.2010.12.012. Epub 2010 Dec 15.
2
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG.异戊烯基化合物的生物合成：[4Fe-4S]簇蛋白 IspG 的晶体结构。
J Mol Biol. 2010 Dec 10;404(4):600-10. doi: 10.1016/j.jmb.2010.09.050. Epub 2010 Oct 7.
3
Reductive dehydroxylation of allyl alcohols by IspH protein.异戊烯基二磷酸脱水酶蛋白催化烯丙醇的还原脱羟反应。
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8802-9. doi: 10.1002/anie.201000833.
4
Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions.(E)-4-羟基-3-甲基-2-丁烯基二磷酸合酶（GcpE/IspG）在稳态和预稳态条件下的顺磁中间产物。
J Am Chem Soc. 2010 Oct 20;132(41):14509-20. doi: 10.1021/ja101764w.
5
Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms.甲基赤藓醇磷酸（MEcPP）在脱氧木酮糖磷酸途径中的合成：环氧化物的合成及机制。
Chem Commun (Camb). 2010 Oct 14;46(38):7220-2. doi: 10.1039/c0cc02594a. Epub 2010 Sep 1.
6
Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin.抗疟候选药物磷霉素高活性反向类似物的合成及其抗疟活性
ChemMedChem. 2010 Oct 4;5(10):1673-6. doi: 10.1002/cmdc.201000276.
7
A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria.一种新型酶家族，可催化细菌中异戊烯醇磷酸（MEP）途径中第一个关键步骤的反应，用于类异戊二烯生物合成。
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14081-6. doi: 10.1073/pnas.1001962107. Epub 2010 Jul 26.
8
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.针对异戊二烯生物合成的药物发现：从实验室到临床。
Acc Chem Res. 2010 Sep 21;43(9):1216-26. doi: 10.1021/ar100026v.
9
Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG).4Fe-4S 异戊烯基生物合成蛋白 GcpE（IspG）的有机金属作用机制和抑制作用。
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11189-93. doi: 10.1073/pnas.1000264107. Epub 2010 Jun 7.
10
Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum.结核分枝杆菌和疟原虫 2-甲基赤藓醇 2,4-环二磷酸合酶（IspF）的噻唑并嘧啶抑制剂。
ChemMedChem. 2010 Jul 5;5(7):1092-101. doi: 10.1002/cmdc.201000083.
Zotero 插件