Pediatric Research Centre, University of Tampere, Finland.
Inflamm Bowel Dis. 2011 Aug;17(8):1778-83. doi: 10.1002/ibd.21550. Epub 2010 Nov 15.
The present study aimed to characterize the incidence of pediatric inflammatory bowel disease (IBD) in Finland and determine its temporal trends.
The patients' data were based on the database of the Social Insurance Institution. New cases diagnosed with IBD at the age <18 years in Finland between years 1987-2003 were included. Annual incidence rates were calculated per 100,000 pediatric populations (with 95% confidence intervals [CI]). The country is divided into 21 hospital districts and regional differences were evaluated accordingly.
The incidence of pediatric IBD increased from 5 per 100,000 in 1987 to 15 per 100,000 in 2003. The average rate of increase was 6.5% per year (95% CI 5.4%-7.5%). The trends were comparable for boys and girls, also by age group. Information on disease subtype was available from 1992 and during this 12-year period the incidence of Crohn's disease (CD) increased from 2-5 per 100,000 and that of ulcerative colitis (UC) from 4-9 per 100,000.
Our results demonstrate a very high incidence rate for childhood IBD and in particular UC in Finland. Furthermore, a rapid increase took place nationwide in the incidence of both CD and UC during the past two decades.
本研究旨在描述芬兰儿科炎症性肠病（IBD）的发病情况，并确定其时间趋势。
患者数据基于社会保险机构的数据库。在芬兰，1987 年至 2003 年间年龄<18 岁的新诊断为 IBD 的患者纳入本研究。每 10 万例儿科人群（95%置信区间[CI]）计算发病率。根据医院区域将该国分为 21 个区域，并进行区域差异评估。
儿科 IBD 的发病率从 1987 年的每 100,000 人 5 例上升至 2003 年的每 100,000 人 15 例。平均年增长率为 6.5%（95%CI 5.4%-7.5%）。男孩和女孩以及不同年龄组的趋势相似。1992 年开始可获得疾病亚型信息，在此 12 年期间，克罗恩病（CD）的发病率从每 100,000 人 2-5 例上升至每 100,000 人 6-11 例，溃疡性结肠炎（UC）的发病率从每 100,000 人 4-9 例上升至每 100,000 人 10-14 例。
我们的研究结果表明，芬兰儿童 IBD 的发病率非常高，尤其是 UC。此外，在过去的二十年中，全国范围内 CD 和 UC 的发病率均呈快速上升趋势。
