Servicio de Aparato Digestivo, Hospital Universitario La Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Inflamm Bowel Dis. 2011 Aug;17(8):1814-21. doi: 10.1002/ibd.21554. Epub 2010 Dec 3.
Studies on angiogenesis and lymphangiogenesis have gained special relevance in research into factors potentially influencing the pathogenesis and course of inflammatory bowel disease (IBD). The results of the few existing studies on the distribution and density of lymphatic vessels and blood vessels in the context of IBD are controversial. Studies using the specific lymphatic marker podoplanin have revealed a significantly large number of lymphatic vessels in the colonic mucosa of patients with ulcerative colitis and Crohn's disease (compared to patients with normal mucosa), whereas other authors have found no significant differences. However, the role of vascular endothelial growth factor (VEGF) tyrosine-kinase receptor 3 (VEGFR-3) in the onset of IBD has not been analyzed. In recent years new biochemical, molecular, and immunohistochemical studies indicate that several families of growth factors, such as the VEGF family and their receptors, fibroblast growth factor-2, platelet-derived growth factor-BB, hepatocyte growth factor, the angiopoietin system, and integrins may play an important role in the onset of IBD. To date, no comparative studies have analyzed these growth factors and specific lymphatic markers. We examine how growth factors are involved in the development of pathological lymphangiogenesis in patients with IBD and determine whether they play a crucial role in disease exacerbation.
在研究可能影响炎症性肠病（IBD）发病机制和病程的因素时，血管生成和淋巴管生成的研究具有特殊的意义。关于 IBD 背景下淋巴管和血管分布和密度的少数现有研究结果存在争议。使用特定的淋巴管标志物 podoplanin 的研究表明，溃疡性结肠炎和克罗恩病患者的结肠黏膜中存在大量淋巴管（与正常黏膜患者相比），而其他作者则没有发现明显差异。然而，血管内皮生长因子（VEGF）酪氨酸激酶受体 3（VEGFR-3）在 IBD 发病机制中的作用尚未得到分析。近年来，新的生化、分子和免疫组织化学研究表明，几种生长因子家族，如 VEGF 家族及其受体、成纤维细胞生长因子-2、血小板衍生生长因子-BB、肝细胞生长因子、血管生成素系统和整合素，可能在 IBD 的发病机制中发挥重要作用。迄今为止，尚无比较研究分析这些生长因子和特定的淋巴管标志物。我们研究了生长因子如何参与 IBD 患者病理性淋巴管生成的发展，并确定它们在疾病恶化中是否起关键作用。
