Hokari Ryota, Tomioka Akira
Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Inflamm Regen. 2021 Aug 17;41(1):25. doi: 10.1186/s41232-021-00175-6.
The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vascular defects have been revealed in inflammatory diseases, Crohn's disease, obesity, cardiovascular disease, hypertension, atherosclerosis, and Alzheimer's disease. In this review, we discuss lymphatic structure and function within the gut, such as dietary lipid absorption, the transport of antigens and immune cells to lymph nodes, peripheral tolerance, and lymphocyte migration from secondary lymphoid tissues to the lymphatics and the immune systems. We also discuss the potential roles of these lymphatics on the pathophysiology of inflammatory bowel disease and as new targets for therapeutic management.
淋巴脉管系统将过滤后的间质动脉液和组织代谢产物返回血液循环。它在脂质吸收和免疫细胞运输中也起着重要作用。在炎症性疾病、克罗恩病、肥胖症、心血管疾病、高血压、动脉粥样硬化和阿尔茨海默病中已发现淋巴管缺陷。在本综述中，我们讨论肠道内的淋巴结构和功能，如膳食脂质吸收、抗原和免疫细胞向淋巴结的运输、外周耐受以及淋巴细胞从二级淋巴组织向淋巴管和免疫系统的迁移。我们还讨论了这些淋巴管在炎症性肠病病理生理学中的潜在作用以及作为治疗管理新靶点的情况。
