Department of Obstetrics and Gynaecology, Santa Maria Hospital, Bari, Italy.
Eur Rev Med Pharmacol Sci. 2011 May;15(5):518-23.
To investigate if early epidural analgesia can influence fetal head engagement into the pelvis and if it can increase the rate of transverse and asynclitic position during labour.
195 women with combined spinal-epidural analgesia (CSE) or without neuraxial analgesia were studied. CSE was performed using a mixture of ropivacaine 0.02% with 0.3 microg/ml of sufentanil administered in the spinal space. Maintenance of analgesia was managed with intermittent epidural administration of 10-15 ml of ropivacaine (0.07%-0.10%) mixed with 0.5 microg/ml of sufentanil, based on the stage of labour and the degree of pain. 2D transabdominal ultrasound (US) was used. Serial transabdominal US examinations were performed at 45-90 min intervals to detect transverse and asynclitic positions, using the following signs: squint sign, sunset thalamus and cerebellum signs that best details the fetal head station. After delivery, the complete set of clinical and US data obtained by each examination were recorded and compared in women with and without labour analgesia. Data were examined by independent reviewers.
There was no difference in obstetric outcome between women in whom CSE had been used and those who did not request analgesia during labour (p > 0.05).
Epidural analgesia initiated early during labour and using low doses does not increase the rate of dystocic labors. Transverse fetal head positioning with anterior or posterior asynclitism does not seem to be promoted by drug or technique-related mechanisms, but rather should be the consequence of cephalopelvic disproportion.
研究分娩早期硬膜外镇痛是否会影响胎头入盆,并增加分娩过程中横位和斜位的发生率。
本研究共纳入 195 例接受蛛网膜下腔-硬膜外联合镇痛(CSE)或未接受脊麻镇痛的产妇。CSE 采用 0.02%罗哌卡因和 0.3μg/ml 舒芬太尼混合液在蛛网膜下腔给药。根据产程阶段和疼痛程度,间歇性硬膜外给予 10-15ml 0.07%-0.10%罗哌卡因和 0.5μg/ml 舒芬太尼维持镇痛。采用二维经腹部超声(US)进行检查。每隔 45-90 分钟进行连续经腹部 US 检查,以发现横位和斜位,使用斜矢状面、日落丘脑和小脑征等征象来最佳描述胎头位置。分娩后,记录并比较有和无分娩镇痛产妇每次检查获得的完整临床和 US 数据。数据由独立评审员进行检查。
使用 CSE 和未请求分娩镇痛的产妇在产科结局方面无差异(p>0.05)。
在分娩早期开始使用低剂量硬膜外镇痛不会增加难产的发生率。胎头横位伴前或后斜位似乎不是药物或技术相关机制引起的,而可能是头盆不称的结果。