Moore H M
National Cancer Institute, Office of Biorepositories and Biospecimen Research, 11400 Rockville Pike, Room 700, Bethesda, Maryland 20852, USA.
Biotech Histochem. 2012 Jan;87(1):18-23. doi: 10.3109/10520295.2011.591833. Epub 2011 Jul 12.
High quality cancer research using human biospecimens must be based on biospecimens that have been obtained according to rigorous ethical and procedural standards. Methods for biospecimen collection, stabilization, processing and storage for research, however, are highly variable and the biospecimens available for research often are of unknown quality. The National Cancer Institute Biospecimen Research Network program was initiated in 2006 to conduct, sponsor, report and collaborate on research to better understand the effects of different biospecimen collection methods on downstream molecular analysis. An online Biospecimen Research Database and an annual symposium, Advancing Cancer Research through Biospecimen Science, have been developed and many research projects are underway to develop a knowledge base from which to develop evidence-based biospecimen standard operating procedures and methods for assessing biospecimen quality. These efforts will enable better cancer research and development efforts.
使用人体生物样本的高质量癌症研究必须基于按照严格的伦理和程序标准获取的生物样本。然而，用于研究的生物样本收集、稳定、处理和存储方法差异很大，可供研究的生物样本质量往往未知。美国国立癌症研究所生物样本研究网络计划于2006年启动，旨在开展、赞助、报告相关研究并进行合作，以更好地了解不同生物样本收集方法对下游分子分析的影响。现已开发了一个在线生物样本研究数据库和一个年度研讨会“通过生物样本科学推进癌症研究”，并且正在进行许多研究项目，以建立一个知识库，从中制定基于证据的生物样本标准操作程序和评估生物样本质量的方法。这些努力将有助于更好地开展癌症研究和开发工作。
