Department of Alcohol, Drugs and Addiction, National Institute for Health and Welfare, Helsinki, Finland.
Steroids. 2011 Nov;76(12):1310-6. doi: 10.1016/j.steroids.2011.06.011. Epub 2011 Jul 2.
The abuse of anabolic androgenic steroids (AASs), such as nandrolone, is not only a problem in the world of sports but is associated with the polydrug use of non-athletes. Among other adverse effects, AAS abuse has been associated with long term or even persistent psychiatric problems. We have previously found that nandrolone decanoate treatment could produce prolonged changes in rats' brain reward circuits associated to drug dependence. The aim in this study was to evaluate whether AAS-induced neurochemical and behavioral changes are reversible. The increases in extracellular dopamine (DA) and serotonin (5-HT) concentration, as well as stereotyped behavior and locomotor activity (LMA) evoked by cocaine were attenuated by pretreatment with nandrolone. The recovery period, which was needed for the DA system to return back to the basic level, was fairly long compared to the dosing period of the steroid. In the 5-HT system, the time that system needed to return back to the basal level, was even longer than in the DA system. The attenuation was still seen though there were no detectable traces of nandrolone in the blood samples. Given that accumbal outflow of DA and 5-HT, as well as LMA and stereotyped behavior are all related to reward of stimulant drugs, this study suggests that nandrolone decanoate has significant, long-lasting but reversible effects on the rewarding properties of cocaine.
合成代谢雄激素类固醇（AASs）的滥用，如诺龙，不仅是体育界的一个问题，而且与非运动员的多药物使用有关。除了其他不良反应外，AAS 滥用与长期甚至持续的精神问题有关。我们之前发现癸酸诺龙治疗可能会导致与药物依赖相关的大鼠大脑奖励回路的长期变化。本研究的目的是评估 AAS 引起的神经化学和行为变化是否可逆。可卡因引起的细胞外多巴胺（DA）和 5-羟色胺（5-HT）浓度的增加，以及刻板行为和运动活动（LMA），通过癸酸诺龙预处理而减弱。与类固醇的给药期相比，DA 系统恢复到基本水平所需的恢复期相当长。在 5-HT 系统中，系统恢复到基础水平所需的时间甚至比 DA 系统还要长。尽管在血液样本中没有检测到诺龙的痕迹，但仍能看到这种衰减。鉴于伏隔核中 DA 和 5-HT 的流出，以及 LMA 和刻板行为都与兴奋剂药物的奖励有关，本研究表明，癸酸诺龙对可卡因的奖励特性具有显著、持久但可逆转的影响。
