Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Republic of Korea.
Food Chem Toxicol. 2011 Sep;49(9):2453-8. doi: 10.1016/j.fct.2011.06.071. Epub 2011 Jul 2.
In the present study, we examined the effect of a mixture of dietary components, including red grape extract, soy isoflavone and L-carnitine (RISC), on obesity. RISC substantially inhibited high-fat diet (HFD)-induced increase in body weight in a dose-dependent manner in C57BL/6 mice. The amount of subcutaneous and mesenteric fat was also significantly decreased by RISC treatment in HFD-fed C57BL/6 mice, whereas epididymal fat was not affected. Moreover, HFD-induced plasma leptin levels were down-regulated by RISC treatment. In these mice, RISC treatment significantly increased the plasma level of high density lipoprotein cholesterol without affecting the level of low density lipoprotein cholesterol and triglycerides. In addition, HFD-induced increase in liver weight and lipid accumulation in liver was significantly suppressed by RISC treatment in C57BL/6mice. Plasma level of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase was also inhibited by RISC treatment. These results demonstrate that RISC suppresses HFD-induced obesity and suggest that RISC supplementation might be a promising adjuvant therapy for the treatment of obesity and its complications, such as cardiovascular and non-alcoholic fatty liver diseases.
在本研究中，我们研究了包括红酒提取物、大豆异黄酮和左旋肉碱在内的膳食成分混合物（RISC）对肥胖的影响。RISC 可显著抑制 C57BL/6 小鼠高脂肪饮食（HFD）诱导的体重增加，并呈剂量依赖性。RISC 处理还可显著减少 HFD 喂养的 C57BL/6 小鼠的皮下和肠系膜脂肪量，而附睾脂肪不受影响。此外，RISC 处理可下调 HFD 诱导的血浆瘦素水平。在这些小鼠中，RISC 处理可显著增加血浆高密度脂蛋白胆固醇水平，而不影响低密度脂蛋白胆固醇和甘油三酯水平。此外，RISC 处理可显著抑制 HFD 诱导的 C57BL/6 小鼠肝重增加和肝内脂质积累。RISC 处理还可抑制血浆谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶水平。这些结果表明，RISC 可抑制 HFD 诱导的肥胖，并提示 RISC 补充可能是肥胖及其并发症（如心血管疾病和非酒精性脂肪肝疾病）治疗的一种有前途的辅助治疗方法。
