Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Toxicol Res. 2014 Mar;30(1):49-54. doi: 10.5487/TR.2014.30.1.049.
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
在这项研究中，我们调查了陈化黑蒜（ABG）对肝损伤啮齿动物模型的保肝作用。ABG 抑制了四氯化碳诱导的 SD 大鼠天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的升高，AST 和 ALT 是肝细胞损伤的标志物。ABG 处理还抑制了半乳糖胺诱导的肝细胞损伤。然而，ABG 对四氯化碳或半乳糖胺处理大鼠碱性磷酸酶（ALP）升高，即肝胆汁损伤的标志物，没有影响。我们还研究了 ABG 对高脂肪饮食（HFD）诱导的脂肪肝和随后的肝损伤的影响。ABG 对 HFD 喂养小鼠的体重增加和血浆脂质谱没有显著影响。然而，ABG 处理显著抑制了 HFD 诱导的 AST 和 ALT 升高，但对 ALP 没有影响。这些结果表明 ABG 具有保肝作用，并提示 ABG 补充可能是管理肝损伤的一种良好辅助治疗方法。
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