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[原发性肝脏良恶性肿瘤的外科治疗]

[Surgery of benign and malignant primary liver tumors].

作者信息

Lerut J, Luder P J, Gertsch P, Blumgart L H

机构信息

Klinik für viszerale und Transplantationschirurgie, Inselspital, Universität Bern.

出版信息

Schweiz Rundsch Med Prax. 1990 Nov 13;79(46):1422-9.

PMID:2174570
Abstract

Better, noninvasive, diagnostics, better knowledge of anatomy and of surgical techniques have been responsible for a considerable development of liver surgery during recent years. Primary malignant liver tumours can only be cured by resection. The decision for resectional surgery should be based on different tumor characteristics, of whom the nature of the liver tissue (normal or cirrhotic) in which the tumor develops in of utmost importance. A malignant tumor should be resected with save, tumor-free margins, leaving behind as much normal functional parenchyma as possible. The role of complementary therapies as e.g. chemotherapy, chemo-embolisation and arterial ischemia must be further developed. Liver transplantation will probably play a more important role in the future development of liver cancer treatment. Surgery for benign liver tumors can be restricted most of the time to a limited resection; extended hepatectomies are rarely necessary. The more deliberate use of intraoperative ultrasound and hepatic vascular exclusion as well as the more frequent use of ultrasound dissectors will allow safer liver surgery; this applies especially for the excision of benign solid liver tumors. Because of their degenerative risks, liver adenomas should be excised. Focal nodular hyperplasia and haemangioma remain rare indications for surgery. The low morbidity and mortality of elective liver resections should favour a more widespread use of surgery for the treatment of malignant as well benign liver tumors.

摘要

近年来,更好的非侵入性诊断方法、对解剖结构和手术技术的更深入了解推动了肝脏外科的显著发展。原发性恶性肝肿瘤只能通过切除治愈。决定进行切除手术应基于不同的肿瘤特征,其中肿瘤所发生的肝组织(正常或肝硬化)的性质至关重要。恶性肿瘤应在确保切缘无瘤的情况下进行切除,尽可能保留更多正常功能的实质组织。诸如化疗、化疗栓塞和动脉缺血等辅助治疗的作用必须进一步拓展。肝移植在未来肝癌治疗的发展中可能会发挥更重要的作用。大多数情况下,良性肝肿瘤的手术可局限于有限切除;很少需要进行扩大肝切除术。更审慎地使用术中超声和肝血管阻断以及更频繁地使用超声解剖器将使肝脏手术更安全;这尤其适用于切除良性实性肝肿瘤。由于肝腺瘤有恶变风险,应予以切除。局灶性结节性增生和肝血管瘤仍是少见的手术指征。择期肝切除的低发病率和死亡率应有利于更广泛地应用手术治疗恶性和良性肝肿瘤。

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