Georgakopoulos Constantine D, Kargiotis Odysseas, Eliopoulou Maria I, Makri Olga E, Exarchou Artemis M, Papathanasopoulos Panagiotis
University of Patras, Patras, Greece.
J Child Neurol. 2011 Dec;26(12):1576-9. doi: 10.1177/0883073811412828. Epub 2011 Jul 10.
We present the case of a 14-year-old girl who was admitted to the hospital with the complaint of horizontal diplopia for 48 hours. Initially, she was diagnosed with idiopathic intracranial hypertension. During hospitalization she developed fever, macular facial rash, and chest pain, and because of abnormal laboratory findings the diagnosis of systemic lupus erythematosus was established. She received immunomodulatory therapy, a combination of corticosteroids, and intravenous infusions of the monoclonal antibody rituximab, which augmented her clinical improvement. Intracranial hypertension secondary to systemic lupus erythematosus is a rare manifestation, especially as a presenting symptom. In addition, the fact that the patient developed an aggressive form of systemic lupus erythematosus during the initial period of hospitalization for idiopathic intracranial hypertension is also uncommon. Moreover, to our knowledge, we are not aware of any published case reports of intracranial hypertension secondary to systemic lupus erythematosus that was treated with rituximab.
我们报告了一例14岁女孩的病例，她因水平复视48小时入院。最初，她被诊断为特发性颅内高压。住院期间，她出现发热、面部斑疹和胸痛，由于实验室检查结果异常，确诊为系统性红斑狼疮。她接受了免疫调节治疗，包括皮质类固醇联合静脉输注单克隆抗体利妥昔单抗，这使她的临床症状有所改善。系统性红斑狼疮继发的颅内高压是一种罕见的表现，尤其是作为首发症状。此外，该患者在因特发性颅内高压住院初期就发展为侵袭性系统性红斑狼疮，这也不常见。而且，据我们所知，我们未意识到有任何关于用利妥昔单抗治疗系统性红斑狼疮继发颅内高压的已发表病例报告。
