Grose C
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.
Annu Rev Microbiol. 1990;44:59-80. doi: 10.1146/annurev.mi.44.100190.000423.
This article reviews major developments concerning the VZV glycoproteins. Very little was published about these viral products prior to the early 1980s. VZV is now known to encode five glycoproteins that have been designated gpI through gpV. The viral glycoproteins are present within the envelope of the complete virion; in addition, they are inserted in the plasma membrane of the infected cell. Studies of the assembly and processing of three of the VZV glycoproteins have demonstrated that they may contain both N-linked and O-linked glycans, some of which are also sulfated and sialated. A heretofore unappreciated modification of VZV gpI is phosphorylation. The glycoprotein is modified on its serine and threonine residues by at least two cellular protein kinases--casein kinases I and II. Finally, aspects of viral glycoprotein trafficking have been analyzed in VZV-infected cells. The pathway progresses from the trans-Golgi region via cytoplasmic vacuoles to the outer cellular membrane. The virus may acquire part of its glycoprotein-laden envelope from the cytoplasmic vacuoles.
本文综述了水痘带状疱疹病毒（VZV）糖蛋白的主要研究进展。在20世纪80年代早期之前，关于这些病毒产物的报道非常少。现在已知VZV编码五种糖蛋白，分别命名为gpI至gpV。病毒糖蛋白存在于完整病毒体的包膜内；此外，它们还插入到被感染细胞的质膜中。对三种VZV糖蛋白的组装和加工研究表明，它们可能同时含有N-连接和O-连接聚糖，其中一些还进行了硫酸化和唾液酸化修饰。VZV gpI一种此前未被重视的修饰是磷酸化。该糖蛋白的丝氨酸和苏氨酸残基至少被两种细胞蛋白激酶——酪蛋白激酶I和II修饰。最后，对VZV感染细胞中病毒糖蛋白的运输过程进行了分析。其途径是从反式高尔基体区域经细胞质空泡运输到细胞外膜。病毒可能从细胞质空泡中获取部分载有糖蛋白的包膜。
