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唾液腺多形性腺瘤和腺样囊性癌中的糖胺聚糖

Glycosaminoglycans in pleomorphic adenoma and adenoid cystic carcinoma of the salivary gland.

作者信息

Nakanishi K, Kawai T, Suzuki M, Shinmei M

机构信息

Department of Pathology, National Defense Medical College, Tokorozawa, Japan.

出版信息

Arch Pathol Lab Med. 1990 Dec;114(12):1227-31.

PMID:2174671
Abstract

One of the common histopathologic features of pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) of the salivary gland is the abundant accumulation of glycosaminoglycans (GAGs). To study a relationship between the histologic distribution of GAGs and the morphologic pattern of salivary gland tumors, we carried out immunohistochemical and biochemical analyses of GAGs on 16 cases of PA and three cases of ACC. Immunohistochemically, several GAG fractions such as chondroitin-6-sulfate, unsulfated chondroitin sulfate, and keratan sulfate were seen mainly at the plasma membrane of both PA and ACC cells and of myoepithelial cells of normal salivary glands. Most of these GAG-positive cells were distributed in solid and chondromyxoid parts of PA and in the cellular part of ACC. Biochemical GAG analysis of both PA and ACC, separated into nonsulfated and sulfated fractions by two-dimensional electrophoresis, revealed high concentrations of chondroitin sulfate in both neoplasms, but the concentration of hyaluronic acid, was significantly higher in PA than in ACC. The results show that the concentration of hyaluronic acid, a major nonsulfated GAG fraction, was significantly higher in PA than in ACC and, therefore, this difference may be useful in the differentiation of the two neoplasms.

摘要

涎腺多形性腺瘤(PA)和腺样囊性癌(ACC)常见的组织病理学特征之一是糖胺聚糖(GAGs)的大量积聚。为了研究GAGs的组织学分布与涎腺肿瘤形态学模式之间的关系,我们对16例PA和3例ACC进行了GAGs的免疫组织化学和生化分析。免疫组织化学显示,硫酸软骨素-6-硫酸盐、非硫酸化硫酸软骨素和硫酸角质素等几种GAG组分主要见于PA和ACC细胞以及正常涎腺肌上皮细胞的质膜。这些GAG阳性细胞大多分布在PA的实性和软骨黏液样部分以及ACC的细胞部分。对PA和ACC进行生化GAG分析,通过二维电泳将其分离为非硫酸化和硫酸化组分,结果显示两种肿瘤中硫酸软骨素浓度均较高,但透明质酸浓度在PA中显著高于ACC。结果表明,作为主要非硫酸化GAG组分的透明质酸浓度在PA中显著高于ACC,因此,这种差异可能有助于鉴别这两种肿瘤。

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