Safoura Seifi, Mohamad Eslami, Nosrat-Allah Eshghyar, Fereshte Ensani
Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
J Cancer Res Ther. 2011 Jan-Mar;7(1):23-8. doi: 10.4103/0973-1482.80440.
The importance of hormone receptor status in diagnosis, prognosis and response to hormone therapy of breast cancer has already been proven.
Morphologic mimicry and similarity between salivary gland tumors and breast tumors led us to undertake an immunohistochemical evaluation on the expression of progesterone receptors (PRs) in pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) of salivary glands.
We researched the role of PRs in tumorigenesis and hormone therapy of PA and ACC with immunohistochemistry and their expression in normal salivary glands was studied. Association of progesterone expression with grade 2 and 3 ACC was researched.
In a descriptive, analytical, cross-sectional study, 29 paraffin blocks (14 samples of PA and 15 samples of ACC) were prepared for immunohistochemical staining with progesterone antibody. t-Test and Mann-Whitney test were used for the statistical analysis of the results.
PR staining was negative in 15 ACC and 13 PA cases. Slight to moderate staining was seen around the tumor in 12 normal cases. Little or no PR staining was observed among endothelial cells, fibroblasts and inflammatory cells. No progesterone expression in grade 2 and 3 ACC in the salivary glands was observed.
Although progesterone seems to be essential for normal function of the salivary glands, it does not have a role in tumorigenesis and hormone therapy in PA and ACC. No association was found between progesterone expression and differentiation grade in ACC.
激素受体状态在乳腺癌的诊断、预后及激素治疗反应中的重要性已得到证实。
涎腺肿瘤与乳腺肿瘤之间的形态学模仿及相似性促使我们对涎腺多形性腺瘤（PA）和腺样囊性癌（ACC）中孕激素受体（PR）的表达进行免疫组化评估。
我们采用免疫组化研究PR在PA和ACC肿瘤发生及激素治疗中的作用，并研究其在正常涎腺中的表达。研究孕激素表达与2级和3级ACC的相关性。
在一项描述性、分析性横断面研究中，制备29个石蜡块（14个PA样本和15个ACC样本）用于孕激素抗体免疫组化染色。结果采用t检验和曼-惠特尼检验进行统计学分析。
15例ACC和13例PA病例PR染色为阴性。12例正常病例在肿瘤周围可见轻度至中度染色。在内皮细胞、成纤维细胞和炎性细胞中未观察到PR染色或仅有少量染色。涎腺2级和3级ACC中未观察到孕激素表达。
虽然孕激素似乎对涎腺的正常功能至关重要，但它在PA和ACC的肿瘤发生及激素治疗中不起作用。在ACC中未发现孕激素表达与分化程度之间存在关联。
