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Where's the gate? Gating in the deep pore of the BK(Ca) channel.

作者信息

Cox Daniel H, Hoshi Toshinori

出版信息

J Gen Physiol. 2011 Aug;138(2):133-6. doi: 10.1085/jgp.201110681. Epub 2011 Jul 11.

DOI:10.1085/jgp.201110681
PMID:21746844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3149440/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d51/3149440/23416dfa6fd9/JGP_201110681_RGB_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d51/3149440/23416dfa6fd9/JGP_201110681_RGB_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d51/3149440/23416dfa6fd9/JGP_201110681_RGB_Fig1.jpg

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Where's the gate? Gating in the deep pore of the BK(Ca) channel.通道门在哪里?BK(Ca)通道深孔中的门控。
J Gen Physiol. 2011 Aug;138(2):133-6. doi: 10.1085/jgp.201110681. Epub 2011 Jul 11.
2
Hydrophobic gating in BK channels.BK 通道的疏水性门控。
Nat Commun. 2018 Aug 24;9(1):3408. doi: 10.1038/s41467-018-05970-3.
3
Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.荷电置换深孔残基揭示 BK 通道门控过程中的结构动力学。
J Gen Physiol. 2011 Aug;138(2):137-54. doi: 10.1085/jgp.201110632. Epub 2011 Jul 11.
4
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Cell Mol Life Sci. 2009 Mar;66(5):852-75. doi: 10.1007/s00018-008-8609-x.
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Tuning the mechanosensitivity of a BK channel by changing the linker length.通过改变连接子长度来调节大电导钙激活钾通道的机械敏感性。
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Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.金属驱动的人类大电导电压和 Ca2+ 依赖性钾通道(BK)门控环装置的操作。
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Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.在MthK钾通道激活过程中,钙离子打开一个选择性过滤器门控。
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本文引用的文献

1
Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.荷电置换深孔残基揭示 BK 通道门控过程中的结构动力学。
J Gen Physiol. 2011 Aug;138(2):137-54. doi: 10.1085/jgp.201110632. Epub 2011 Jul 11.
2
Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.半胱氨酸扫描和修饰揭示了内孔区域 BK 通道和 Kv 通道之间的主要差异。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12161-6. doi: 10.1073/pnas.1104150108. Epub 2011 Jul 5.
3
Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume.
TWIK-1 K2P钾通道内孔深处的疏水屏障。
Nat Commun. 2014 Jul 8;5:4377. doi: 10.1038/ncomms5377.
4
DiBAC₄(3) hits a "sweet spot" for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit.DiBAC₄(3) 通过非β₁亚基独立激活动脉大电导钙激活钾通道的“最佳位置”。
Am J Physiol Heart Circ Physiol. 2013 Jun 1;304(11):H1471-82. doi: 10.1152/ajpheart.00939.2012. Epub 2013 Mar 29.
5
Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.观点:离子通道中的构象偶联:BK 钾通道中的构象偶联。
J Gen Physiol. 2012 Dec;140(6):625-34. doi: 10.1085/jgp.201210849.
6
Cytoplasmic domains and voltage-dependent potassium channel gating.细胞质结构域与电压依赖性钾通道门控
Front Pharmacol. 2012 Mar 23;3:49. doi: 10.3389/fphar.2012.00049. eCollection 2012.
7
An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate.辅助β1 亚基的细胞外结构域是调节 BK 通道电压传感器和门控所必需的。
J Gen Physiol. 2012 Jan;139(1):57-67. doi: 10.1085/jgp.201110698. Epub 2011 Dec 12.
BK 通道内腔小尺寸、低电阻入口由侧链体积变化决定。
J Gen Physiol. 2011 Jun;137(6):533-48. doi: 10.1085/jgp.201110616. Epub 2011 May 16.
4
Structural mechanism of C-type inactivation in K(+) channels.钾离子通道 C 型失活的结构机制。
Nature. 2010 Jul 8;466(7303):203-8. doi: 10.1038/nature09153.
5
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.人类 BK 通道钙激活装置的结构在 3.0A 分辨率下。
Science. 2010 Jul 9;329(5988):182-6. doi: 10.1126/science.1190414. Epub 2010 May 27.
6
Principles of conduction and hydrophobic gating in K+ channels.K+ 通道的传导和疏水性门控原理。
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5833-8. doi: 10.1073/pnas.0911691107. Epub 2010 Mar 15.
7
Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.CTX、IbTX、TEA、4-AP 和奎尼丁对小鼠 slo1 和 slo3 K+通道的阻断作用。
Channels (Austin). 2010 Jan-Feb;4(1):22-41. doi: 10.4161/chan.4.1.10481. Epub 2010 Jan 2.
8
Gating at the selectivity filter in cyclic nucleotide-gated channels.环核苷酸门控通道中选择性过滤器的门控
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3310-4. doi: 10.1073/pnas.0709809105. Epub 2008 Feb 20.
9
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.脂质膜样环境中电压依赖性钾离子通道的原子结构。
Nature. 2007 Nov 15;450(7168):376-82. doi: 10.1038/nature06265.
10
State-dependent block of BK channels by synthesized shaker ball peptides.合成的Shaker球肽对大电导钙激活钾通道的状态依赖性阻断
J Gen Physiol. 2006 Oct;128(4):423-41. doi: 10.1085/jgp.200609521. Epub 2006 Sep 11.